Abstract
This chapter concludes the survey of experimental and clinical data on the analgesic and antitussive properties of codeine and its potential therapeutic alternates. From an evaluation of their effectiveness on the one hand and the side-effects, including tolerance, dependence and abuse liability on the other, it would appear that the therapeutic goals of codeine could be achieved by other substances, except perhaps where analgesia, cough relief, and sedation are required simultaneously. The use of these other substances would, however, result in no particular gain and probably no particular loss.
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Selected References
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- BELLVILLE J. W., WALLENSTEIN S. L., WALD G. H., DOWLING M. D., Jr, HOUDE R. W. Effect of noscapine and codeine on the respiratory response to carbon dioxide. Anesthesiology. 1958 Jul-Aug;19(4):545–551. doi: 10.1097/00000542-195807000-00012. [DOI] [PubMed] [Google Scholar]
- BICKERMAN H. A., GERMAN E., COHEN B. M., ITKIN S. E. The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents. Am J Med Sci. 1957 Aug;234(2):191–206. doi: 10.1097/00000441-195708000-00010. [DOI] [PubMed] [Google Scholar]
- BICKERMAN H. A., ITKIN S. E. Further studies on the evaluation of antitussive agents employing experimentally induced cough in human subjects. Clin Pharmacol Ther. 1960 Mar-Apr;1:180–191. doi: 10.1002/cpt196012180. [DOI] [PubMed] [Google Scholar]
- BOYD E. M. The cough syrup. Br Med J. 1946 Nov 16;2(4480):735–735. doi: 10.1136/bmj.2.4480.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CASS L. J., FREDERIK W. S., ANDOSCA J. B. Quantitative comparison of dextromethorphan hydrobromide and codeine. Am J Med Sci. 1954 Mar;227(3):291–296. [PubMed] [Google Scholar]
- CASS L. J., FREDERIK W. S. Evaluation of a new antitussive agent. N Engl J Med. 1953 Jul 23;249(4):132–136. doi: 10.1056/NEJM195307232490402. [DOI] [PubMed] [Google Scholar]
- CASS L. J., LAING J. T., FREDERIK W. S. Physical dependence potentiality of analgesics. Curr Ther Res Clin Exp. 1961 Jul;3:289–299. [PubMed] [Google Scholar]
- Doyle F. P., Mehta M. D. Antitussives. Adv Drug Res. 1964;1:107–159. [PubMed] [Google Scholar]
- EDDY N. B., HALBACH H., BRAENDEN O. J. Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability. Bull World Health Organ. 1957;17(4-5):569–863. [PMC free article] [PubMed] [Google Scholar]
- GRAVENSTEIN J. S., DEVLOO R. A., BEECHER H. K. Effect of antitussive agents on experimental and pathological cough in man. J Appl Physiol. 1954 Sep;7(2):119–139. doi: 10.1152/jappl.1954.7.2.119. [DOI] [PubMed] [Google Scholar]
- Renovanz H. D., Liebrich K. G. Prüfung von Hustenmitteln, dargestellt am Beispiel von 1-p-Chlorphenyl-2,3-dimethyl-4-dimethylamino-butanol-(2).HCl. Arzneimittelforschung. 1965 Dec;15(12):1393–1411. [PubMed] [Google Scholar]
- SWYER P. R. Cough. Can Med Assoc J. 1956 Sep 15;75(6):524–525. [PMC free article] [PubMed] [Google Scholar]
- WOOLF C. R., ROSENBERG A. OBJECTIVE ASSESSMENT OF COUGH SUPPRESSANTS UNDER CLINICAL CONDITIONS USING A TAPE RECORDER SYSTEM. Thorax. 1964 Mar;19:125–130. doi: 10.1136/thx.19.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
