Abstract
Studies of the comparative toxicity of more than 120 DDT analogues to susceptible and insecticide-resistant houseflies (Musca domestica L.) and mosquitos (Culex fatigans Wiedemann and Anopheles albimanus Wiedemann) have shown that the relative effectiveness of these compounds against DDT-resistant insects is correlated with the susceptibility of the molecule to attack by DDT-ase at the benzylic hydrogen. Compounds highly effective against DDT-resistant flies and mosquitos are produced by blocking this detoxication mechanism by o-chlorination, α-fluorination, and by altering the aliphatic portion of the molecule as in the nitropropyl, neopentyl, dichlorocyclopropyl, and trichlorobenzanilide derivatives. These compounds offer practical possibilities for the control of DDT-resistant insects. The correlation of structure, DDT-like activity, and resistance ratios gives new insight into the mode of action of DDT and the nature of DDT resistance.
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Selected References
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- GUNTHER F. A., BLINN R. C., CARMAN G. E., METCALF R. L. Mechanisms of insecticidal action; the structural topography theory and DDT-type compounds. Arch Biochem Biophys. 1954 Jun;50(2):504–505. doi: 10.1016/0003-9861(54)90067-3. [DOI] [PubMed] [Google Scholar]
- HENNESSY D. J., FRATANTONI J., HARTIGAN J., MOORE-FIELD H. H., WEIDEN M. H. Toxicity of 2-(2-halogen-4-chlorophenyl)-2-(4-chlorophenyl)-1.1.1-trichloroethanes to normal and to DDT-resistant house-files. Nature. 1961 Apr 22;190:341–341. doi: 10.1038/190341a0. [DOI] [PubMed] [Google Scholar]
- Perry A. S., Hennessy D. J., Miles J. W. Comparative toxicity and metabolism of p,p'-DDT and various substituted DDT-derivatives by susceptible and resistant house flies. J Econ Entomol. 1967 Apr;60(2):568–573. doi: 10.1093/jee/60.2.568. [DOI] [PubMed] [Google Scholar]