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. 1984 Jan;49(1):297–299. doi: 10.1128/jvi.49.1.297-299.1984

A new oncogene, c-raf, is located on mouse chromosome 6.

C Kozak, M A Gunnell, U R Rapp
PMCID: PMC255459  PMID: 6690719

Abstract

The recently described acute transforming virus 3611-MSV contains cellular sequences designated v-raf. Mouse cellular DNA contains a single-copy sequence homologous to this oncogene (c-raf), and Southern blot analysis of hamster-mouse somatic cell hybrid DNAs showed that the mouse c-raf sequence is present on chromosome 6.

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Selected References

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  1. Bishop J. M. Cellular oncogenes and retroviruses. Annu Rev Biochem. 1983;52:301–354. doi: 10.1146/annurev.bi.52.070183.001505. [DOI] [PubMed] [Google Scholar]
  2. Breindl M., Doehmer J., Willecke K., Dausman J., Jaenisch R. Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1938–1942. doi: 10.1073/pnas.76.4.1938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Crews S., Barth R., Hood L., Prehn J., Calame K. Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science. 1982 Dec 24;218(4579):1319–1321. doi: 10.1126/science.7146913. [DOI] [PubMed] [Google Scholar]
  4. Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R. C., Croce C. M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824–7827. doi: 10.1073/pnas.79.24.7824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Der C. J., Krontiris T. G., Cooper G. M. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A. 1982 Jun;79(11):3637–3640. doi: 10.1073/pnas.79.11.3637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goff S. P., D'Eustachio P., Ruddle F. H., Baltimore D. Chromosomal assignment of the endogenous proto-oncogene C-abl. Science. 1982 Dec 24;218(4579):1317–1319. doi: 10.1126/science.6293057. [DOI] [PubMed] [Google Scholar]
  7. Hayward W. S., Neel B. G., Astrin S. M. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature. 1981 Apr 9;290(5806):475–480. doi: 10.1038/290475a0. [DOI] [PubMed] [Google Scholar]
  8. Klein G. Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Cell. 1983 Feb;32(2):311–315. doi: 10.1016/0092-8674(83)90449-x. [DOI] [PubMed] [Google Scholar]
  9. Kozak C. A., Lawrence J. B., Ruddle F. H. A sequential staining technique for the chromosomal analysis of the interspecific mouse/hamster and mouse/human somatic cell hybrids. Exp Cell Res. 1977 Mar 1;105(1):109–117. doi: 10.1016/0014-4827(77)90156-2. [DOI] [PubMed] [Google Scholar]
  10. Kozak C. A., Rowe W. P. Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5. Science. 1979 Apr 6;204(4388):69–71. doi: 10.1126/science.219475. [DOI] [PubMed] [Google Scholar]
  11. Kozak C. A., Rowe W. P. Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse. J Exp Med. 1980 Nov 1;152(5):1419–1423. doi: 10.1084/jem.152.5.1419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kozak C. A., Sears J. F., Hoggan M. D. Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7. J Virol. 1983 Jul;47(1):217–220. doi: 10.1128/jvi.47.1.217-220.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kozak C., Nichols E., Ruddle F. H. Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet. 1975 Oct;1(4):371–382. doi: 10.1007/BF01538668. [DOI] [PubMed] [Google Scholar]
  14. Ohno S., Babonits M., Wiener F., Spira J., Klein G., Potter M. Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas. Cell. 1979 Dec;18(4):1001–1007. doi: 10.1016/0092-8674(79)90212-5. [DOI] [PubMed] [Google Scholar]
  15. Parada L. F., Tabin C. J., Shih C., Weinberg R. A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 1982 Jun 10;297(5866):474–478. doi: 10.1038/297474a0. [DOI] [PubMed] [Google Scholar]
  16. Rapp U. R., Birkenmeier E., Bonner T. I., Gonda M. A., Gunnell M. Genome structure of mink cell focus-forming murine leukemia virus in epithelial mink lung cells transformed vitro by iododeoxyuridine-induced C3H/MuLV cells. J Virol. 1983 Feb;45(2):740–754. doi: 10.1128/jvi.45.2.740-754.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rapp U. R., Goldsborough M. D., Mark G. E., Bonner T. I., Groffen J., Reynolds F. H., Jr, Stephenson J. R. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4218–4222. doi: 10.1073/pnas.80.14.4218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rapp U. R., Reynolds F. H., Jr, Stephenson J. R. New mammalian transforming retrovirus: demonstration of a polyprotein gene product. J Virol. 1983 Mar;45(3):914–924. doi: 10.1128/jvi.45.3.914-924.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rapp U. R., Todaro C. Generation of new mouse sarcoma viruses in cell culture. Science. 1978 Sep 1;201(4358):821–824. doi: 10.1126/science.210501. [DOI] [PubMed] [Google Scholar]
  20. Rapp U. R., Todaro G. J. Generation of oncogenic mouse type C viruses: in vitro selection of carcinoma-inducing variants. Proc Natl Acad Sci U S A. 1980 Jan;77(1):624–628. doi: 10.1073/pnas.77.1.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rowley J. D. Human oncogene locations and chromosome aberrations. Nature. 1983 Jan 27;301(5898):290–291. doi: 10.1038/301290a0. [DOI] [PubMed] [Google Scholar]
  22. Santos E., Tronick S. R., Aaronson S. A., Pulciani S., Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 1982 Jul 22;298(5872):343–347. doi: 10.1038/298343a0. [DOI] [PubMed] [Google Scholar]
  23. Swan D., Oskarsson M., Keithley D., Ruddle F. H., D'Eustachio P., Vande Woude G. F. Chromosomal localization of the Moloney sarcoma virus mouse cellular (c-mos) sequence. J Virol. 1982 Nov;44(2):752–754. doi: 10.1128/jvi.44.2.752-754.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Taub R., Kirsch I., Morton C., Lenoir G., Swan D., Tronick S., Aaronson S., Leder P. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7837–7841. doi: 10.1073/pnas.79.24.7837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. de Klein A., van Kessel A. G., Grosveld G., Bartram C. R., Hagemeijer A., Bootsma D., Spurr N. K., Heisterkamp N., Groffen J., Stephenson J. R. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982 Dec 23;300(5894):765–767. doi: 10.1038/300765a0. [DOI] [PubMed] [Google Scholar]

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