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. 1969;40(2):279–286.

Transmission of smallpox by contact and by aerosol routes in Macaca irus*

John Noble Jr, James A Rich
PMCID: PMC2554603  PMID: 4308335

Abstract

Smallpox is believed not to occur naturally in species other than man. However, reports of several epizootics of an exanthematous disease, similar to smallpox, in wild monkeys have raised the question of a simian reservoir. If such a reservoir for smallpox exists, the eradication of this disease from the world would be a difficult or impossible task. Transmission of smallpox in Macaca irus has been studied to determine whether transmission occurs and if infection chains can be maintained by this species.

Transmission was consistently accomplished by both contact and aerosol routes. In the contact transmission studies, the smallpox infection was maintained through 6 passages but was lost with the seventh passage. The virulence of the virus did not appear to increase as the virus was serially passed in monkeys. Continuing studies of the possible occurrence of smallpox and of monkeypox in simian populations are warranted.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arita I., Henderson D. A. Smallpox and monkeypox in non-human primates. Bull World Health Organ. 1968;39(2):277–283. [PMC free article] [PubMed] [Google Scholar]
  2. BRAS G. The morbid anatomy of smallpox. Doc Med Geogr Trop. 1952 Dec;4(4):303–351. [PubMed] [Google Scholar]
  3. Downie A. W., Meiklejohn M., St Vincent L., Rao A. R., Sundara Babu B. V., Kempe C. H. The recovery of smallpox virus from patients and their environment in a smallpox hospital. Bull World Health Organ. 1965;33(5):615–622. [PMC free article] [PubMed] [Google Scholar]
  4. HAHON N., McGAVRAN M. H. Air-borne infectivity of the variola-vaccinia group of poxviruses for the cynomolgus monkey, Macaca irus. J Infect Dis. 1961 Nov-Dec;109:294–298. doi: 10.1093/infdis/109.3.294. [DOI] [PubMed] [Google Scholar]
  5. HAHON N. Smallpox and related poxvirus infections in the simian host. Bacteriol Rev. 1961 Dec;25:459–476. doi: 10.1128/br.25.4.459-476.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HAHON N., WILSON B. J. Pathogenesis of variola in Macaca irus monkeys. Am J Hyg. 1960 Jan;71:69–80. doi: 10.1093/oxfordjournals.aje.a120091. [DOI] [PubMed] [Google Scholar]
  7. HEUSCHELE W. P. Varicella (chicken pox) in three young anthropoid apes. J Am Vet Med Assoc. 1960 Mar 15;136:256–257. [PubMed] [Google Scholar]
  8. MCCONNELL S., HERMAN Y. F., MATTSON D. E., HUXSOLL D. L., LANG C. M., YAGER R. H. PROTECTION OF RHESUS MONKEYS AGAINST MONKEYPOX BY VACCINIA VIRUS IMMUNIZATION. Am J Vet Res. 1964 Jan;25:192–195. [PubMed] [Google Scholar]
  9. MEYER H. M., Jr, BROOKS B. E., DOUGLAS R. D., ROGERS N. G. Ecology of measles in monkeys. Am J Dis Child. 1962 Mar;103:307–313. doi: 10.1001/archpedi.1962.02080020319025. [DOI] [PubMed] [Google Scholar]
  10. MacCALLUM F. O., McPHERSON C. A., JOHNSTONE D. F. Laboratory investigation of smallpox patients with particular reference to infectivity in the early stages. Lancet. 1950 Nov 11;2(6637):514–517. doi: 10.1016/s0140-6736(50)91497-8. [DOI] [PubMed] [Google Scholar]
  11. Magrath G. B., Brinckerhoff W. R. On Experimental Variola in the Monkey. J Med Res. 1904 Feb;11(1):230–246.1. [PMC free article] [PubMed] [Google Scholar]
  12. SAUER R. M., PRIER J. E., BUCHANAN R. S., CREAMER A. A., FEGLEY H. C. Studies on a pox disease of monkeys. I. Pathology. Am J Vet Res. 1960 May;21:377–380. [PubMed] [Google Scholar]
  13. Westwood J. C., Boulter E. A., Bowen E. T., Maber H. B. Experimental respiratory infection with poxviruses. I. Clinical virological and epidemiological studies. Br J Exp Pathol. 1966 Oct;47(5):453–465. [PMC free article] [PubMed] [Google Scholar]

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