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. 1969;40(2):177–185.

Report of the 1966-67 cholera vaccine field trial in rural East Pakistan*

1. Study design and results of the first year of observation

Wiley H Mosley, William M McCormack, M Fahimuddin, K M A Aziz, A S M Mizanur Rahman, A K M Alauddin Chowdhury, Albert R Martin, John C Feeley, Robert A Phillips
PMCID: PMC2554610  PMID: 5306538

Abstract

A controlled cholera vaccine field trial was carried out in rural East Pakistan during the 1966-67 cholera season. A commercial cholera vaccine of average potency was tested in 40 000 children aged 3 months to 14 years in 1- and 2-dose schedules. In the cholera season extending for 8 months following immunization, a single dose produced an over-all protection of 46%; 2 doses at an interval of 1 month provided 64% protection. The single dose was virtually ineffective in children under 5 years, but provided significant protection in older children. The enhanced effect of the 2-dose schedule was primarily due to the boosting of protection in children under the age of 5 years. The duration of significant protection, even with the 2-dose schedule, did not appear to extend beyond the first 3 months of the 8-month cholera season.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benenson A. S., Mosley W. H., Fahimuddin M., Oseasohn R. O. Cholera vaccine field trials in east Pakistan. 2. Effectiveness in the field. Bull World Health Organ. 1968;38(3):359–372. [PMC free article] [PubMed] [Google Scholar]
  2. FEELEY J. C., PITTMAN M. LABORATORY ASSAYS OF CHOLERA VACCINE USED IN FIELD TRIAL IN EAST PAKISTAN, 1963. Lancet. 1965 Feb 27;1(7383):449–450. doi: 10.1016/s0140-6736(65)91585-0. [DOI] [PubMed] [Google Scholar]
  3. McCormack W. M., Rahman A. S., Chowdhury A. K., Mosley W. H., Phillips R. A. Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 3. The lack of effect of prior vaccination or circulating vibriocidal antibody on the severity of clinical cholera. Bull World Health Organ. 1969;40(2):199–204. [PMC free article] [PubMed] [Google Scholar]
  4. Mosley W. H., Benenson A. S., Barui R. A serological survey for cholear antibodies in rural east Pakistan. 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera. Bull World Health Organ. 1968;38(3):327–334. [PMC free article] [PubMed] [Google Scholar]
  5. Mosley W. H., McCormack W. M., Ahmed A., Chowdhury A. K., Barui R. K. Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 2. Results of the serological surveys in the study population--the relationship of case rate to antibody titre and an estimate of the inapparent infection rate with Vibrio cholerae. Bull World Health Organ. 1969;40(2):187–197. [PMC free article] [PubMed] [Google Scholar]
  6. OSEASOHN R. O., BENENSON A. S., FAHIMUDDIN M. FIELD TRIAL OF CHOLERA VACCINE IN RURAL EAST PAKISTAN. FIRST YEAR OF OBSERVATION. Lancet. 1965 Feb 27;1(7383):450–452. doi: 10.1016/s0140-6736(65)91586-2. [DOI] [PubMed] [Google Scholar]
  7. PITTMAN M., FEELEY J. C. Protective activity of cholera vaccines against E1 Tor cholera vibrios. Bull World Health Organ. 1963;28(3):379–383. [PMC free article] [PubMed] [Google Scholar]

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