Abstract
In an attempt to determine the specific local action of antirabies serum and antirabies gamma-globulin preparations in vivo, experiments were carried out on mice infected with fixed rabies virus in the pad of the foot and then given inoculations of either of these preparations in the same and in the opposite foot at various intervals thereafter.
Good evidence was obtained of the local protective effect of antirabies serum and, to a lesser degree, of antirabies gamma-globulin when inoculated one hour after infection. Some protection was also apparent when the inoculations were made up to three hours after infection, but none could be demonstrated at six hours.
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Selected References
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- COHEN D., KOPROWSKI H., WIKTUR T. J. A note on local treatment of mice infected intraplantarily with rabies virus. Bull World Health Organ. 1962;26:831–832. [PMC free article] [PubMed] [Google Scholar]
- GOLDWASSER R. A., KISSLING R. E., CARSKI T. R., HOSTY T. S. Fluorescent antibody staining of rabies virus antigens in the salivary glands of rabid animals. Bull World Health Organ. 1959;20:579–588. [PMC free article] [PubMed] [Google Scholar]
- KAPLAN M. M., COHEN D., KOPROWSKI H., DEAN D., FERRIGAN L. Studies on the local treatment of wounds for the prevention of rabies. Bull World Health Organ. 1962;26:765–775. [PMC free article] [PubMed] [Google Scholar]
- KAPLAN M. M., WECKER E., FORSEK Z., KOPROWSKI H. An indicator plaque-forming system for demonstration of interference by non-cytocidal strains of rabies virus. Nature. 1960 Jun 4;186:821–822. doi: 10.1038/186821a0. [DOI] [PubMed] [Google Scholar]
- SOLOVIEV V. D., KOBRINSKI G. D. Local application of antirabies gamma-globulin in dried form for the prevention of rabies. Bull World Health Organ. 1962;26:777–782. [PMC free article] [PubMed] [Google Scholar]