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. 1964;30(1):29–44.

Studies on a strain of chloroquine-resistant Plasmodium falciparum from Thailand*

Robin D Powell, George J Brewer, Alf S Alving, Jack W Millar
PMCID: PMC2554896  PMID: 14128765

Abstract

Infections with a strain of Plasmodium falciparum from Thailand, termed the Thailand (JHK) strain, were established in 25 non-immune volunteers in a non-endemic area under conditions precluding reinfection. Eleven volunteers received chloroquine in usually curative doses on a three-day schedule during acute clinical malaria attacks. Volunteers also received (again during acute clinical attacks) hydroxychloroquine, amodiaquine, mepacrine, pyrimethamine, proguanil or 377-C-54, alone or in combination. These regimens failed, both before and after passage of the strain through mosquitos, to effect radical cure of the infection. Radical cure was achieved by administration of 1350 mg or 1620 mg of quinine base daily for seven days.

The authors point out that resistance to chloroquine by P. falciparum is being recognized with increasing frequency in South America and South-East Asia, and that the effect of this on global chemotherapy of malaria may be serious.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alving A. S., Craige B., Pullman T. N., Whorton C. M., Jones R., Eichelberger L. PROCEDURES USED AT STATEVILLE PENITENTIARY FOR THE TESTING OF POTENTIAL ANTIMALARIAL AGENTS. J Clin Invest. 1948 May;27(3 Pt 2):2–5. doi: 10.1172/JCI101956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOX E. D., BOX Q. T., YOUNG M. D. CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM PORTO VELHO, BRAZIL. Am J Trop Med Hyg. 1963 May;12:300–304. doi: 10.4269/ajtmh.1963.12.300. [DOI] [PubMed] [Google Scholar]
  3. BRUCE-CHWATT L. J., CHARLES L. J. First field trial of 377 C 54, a new antimalarial compound. Br Med J. 1957 Jul 6;2(5035):23–26. doi: 10.1136/bmj.2.5035.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HASKINS W. T. A simple qualitative test for chloroquine in urine. Am J Trop Med Hyg. 1958 Mar;7(2):199–200. doi: 10.4269/ajtmh.1958.7.199. [DOI] [PubMed] [Google Scholar]
  5. MOORE D. V., LANIER J. E. Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. Am J Trop Med Hyg. 1961 Jan;10:5–9. doi: 10.4269/ajtmh.1961.10.5. [DOI] [PubMed] [Google Scholar]
  6. POWELL R. D., BREWER G. J., ALVING A. S. STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM COLOMBIA, SOUTH AMERICA. Am J Trop Med Hyg. 1963 Jul;12:509–512. doi: 10.4269/ajtmh.1963.12.509. [DOI] [PubMed] [Google Scholar]
  7. RAY A. P., SINGH N., GUPTA GP SEN, MISRA B. G. Therapeutic response to a newer antimalarial, 377-C-54. J Indian Med Assoc. 1959 May 16;32(10):398–401. [PubMed] [Google Scholar]
  8. YOUNG M. D. Amodiaquine and hydroxychloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg. 1961 Sep;10:689–693. doi: 10.4269/ajtmh.1961.10.689. [DOI] [PubMed] [Google Scholar]
  9. YOUNG M. D., CONTACOS P. G., STITCHER J. E., MILLAR J. W. DRUG RESISTANCE IN PLASMODIUM FALCIPARUM FROM THAILAND. Am J Trop Med Hyg. 1963 May;12:305–314. doi: 10.4269/ajtmh.1963.12.305. [DOI] [PubMed] [Google Scholar]
  10. YOUNG M. D. Failure of chloroquine and amodiaquine to suppress Plasmodium falciparum. Trans R Soc Trop Med Hyg. 1962 May;56:252–256. doi: 10.1016/0035-9203(62)90164-5. [DOI] [PubMed] [Google Scholar]
  11. YOUNG M. D., MOORE D. V. Chloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg. 1961 May;10:317–320. doi: 10.4269/ajtmh.1961.10.317. [DOI] [PubMed] [Google Scholar]

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