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. 1984 Feb;49(2):591–593. doi: 10.1128/jvi.49.2.591-593.1984

Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity.

S Bacchetti, M J Evelegh, B Muirhead, C S Sartori, D Huszar
PMCID: PMC255503  PMID: 6319760

Abstract

Mammalian cells infected with herpes simplex virus (HSV) express a novel ribonucleotide reductase which is biochemically and immunologically distinct from the uninfected-cell enzyme. Using polyvalent rabbit antiserum raised against partially purified HSV type 2 reductase as well as monoclonal antibodies to HSV type 1 and HSV type 2 early antigens, we have been able to show that in both serotypes reductase activity is associated with phosphoproteins of molecular weights 144,000 and 38,000 encoded between map units 0.566 and 0.602 in the viral genomes. The major antigenic species (144,000) have been tentatively identified as HSV type 1 ICP6 and HSV type 2 ICP10.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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