Abstract
Measles has had particularly serious effects when epidemics have occurred in isolated susceptible adult populations and hence the newly developed measles vaccines may be of special importance to these groups. This paper reports on one of the first sizeable trials of live-virus vaccine (Enders Edmonston B strain) in a group of measles-susceptible adults. Over 700 persons, mostly adults, were vaccinated in Iceland in 1962. Detailed records of the reactions in the vaccinated and control groups were obtained and serological tests were made on paired serum specimens. The reactions in all age-groups were basically similar and showed only minor differences in severity. The incubation period was found to increase progressively with age. As well as confirming the general safety of the Enders live measles virus vaccine in adults, this study provides new information on the nature of the reactions induced by measles vaccine and on the comparative immunological response of various age-groups.
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Selected References
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- BLACK F. L. Measles antibody prevalence in diverse populations. Am J Dis Child. 1962 Mar;103:242–249. doi: 10.1001/archpedi.1962.02080020254011. [DOI] [PubMed] [Google Scholar]
- BLACK F. L., YANNET H. Inapparent measles after gamma globulin administration. JAMA. 1960 Jul 16;173:1183–1188. doi: 10.1001/jama.1960.03020290009002. [DOI] [PubMed] [Google Scholar]
- FOG-POULSEN M. Maeslingeepidemier i Grønland. Ugeskr Laeger. 1957 Apr 25;119(17):509–520. [PubMed] [Google Scholar]
- KATZ S. L., ENDERS J. F., HOLLOWAY A. Use of Edmonston attenuated measles strain. A summary of three years' experience. Am J Dis Child. 1962 Mar;103:340–344. doi: 10.1001/archpedi.1962.02080020352031. [DOI] [PubMed] [Google Scholar]
- KRUGMAN S., GILES J. P., JACOBS A. M., FRIEDMAN H. Studies with live attenuated measles-virus vaccine. Comparative clinical, antigenic, and prophylactic effects after inoculation with and without gamma-globulin. Am J Dis Child. 1962 Mar;103:353–363. [PubMed] [Google Scholar]
- PEART A. F., NAGLER F. P. Measles in the Canadian Arctic, 1952. Can J Public Health. 1954 Apr;45(4):146–156. [PubMed] [Google Scholar]
- ROSEN L. Hemagglutination and hemagglutination-inhibition with measles virus. Virology. 1961 Jan;13:139–141. doi: 10.1016/0042-6822(61)90042-3. [DOI] [PubMed] [Google Scholar]