Abstract
The authors have investigated the spread of fixed and street strains of rabies virus from the site of injection to the central nervous system and salivary glands in various animal species. The results indicate conclusively that rabies virus is ordinarily transmitted from the site of exposure to the central nervous system via the peripheral nerves but that other than nerve transmission may occur in young animals, in highly susceptible species or in animals whose resistance has been altered by trauma or shock. Air-borne infection is occasionally possible. Blood-borne infection in nature is believed to be exceptional and less likely to occur in man, whose resistance to rabies is high, than in animals of species known to be highly susceptible. Evidence of nerve-borne transmission was also observed with herpes simplex virus but not with lymphocytic choriomeningitis virus or the GD7 and FA strains of mouse encephalomyelitis virus.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONSTANTINE D. G. Rabies transmission by nonbite route. Public Health Rep. 1962 Apr;77:287–289. [PMC free article] [PubMed] [Google Scholar]
- DEAN D. J., BAER G. M., THOMPSON W. R. Studies on the local treatment of rabies-infected wounds. Bull World Health Organ. 1963;28(4):477–486. [PMC free article] [PubMed] [Google Scholar]
- GOLDWASSER R. A., KISSLING R. E. Fluorescent antibody staining of street and fixed rabies virus antigens. Proc Soc Exp Biol Med. 1958 Jun;98(2):219–223. doi: 10.3181/00379727-98-23996. [DOI] [PubMed] [Google Scholar]
- HOTCHIN J., WEIGAND H. Studies of lymphocytic choriomeningitis in mice. I. The relationship between age at inoculation and outcome of infection. J Immunol. 1961 Apr;86:392–400. [PubMed] [Google Scholar]
- KAPLAN M. M., COHEN D., KOPROWSKI H., DEAN D., FERRIGAN L. Studies on the local treatment of wounds for the prevention of rabies. Bull World Health Organ. 1962;26:765–775. [PMC free article] [PubMed] [Google Scholar]
- KOPROWSKI H., COX H. R. Studies on chick embryo adapted rabies virus; culture characteristics and pathogenicity. J Immunol. 1948 Dec;60(4):533–554. [PubMed] [Google Scholar]
- Thompson W. R. USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods. Bacteriol Rev. 1947 Jun;11(2):115–145. [PMC free article] [PubMed] [Google Scholar]
- WIKTOR T. J., KOPROWSKI H. [Local action of various drugs on rabies infection in mice]. Bull World Health Organ. 1963;28(4):487–494. [PMC free article] [PubMed] [Google Scholar]
- WONG D. H., FREUND J. Fixed rabies virus in blood following intracerebral inoculation in mice and rabbits. Proc Soc Exp Biol Med. 1951 Apr;76(4):717–720. doi: 10.3181/00379727-76-18605. [DOI] [PubMed] [Google Scholar]