Abstract
Fluorescent antibody procedures have in a short time become valued techniques for the detection of many pathogenic micro-organisms, and are used in syphilis, for instance. A fluorescent antibody test has also been proposed for use in gonorrhoea, but the author of this paper suggests that there are still many questions to be answered before that test can be recommended for widespread practical application. In particular, large-scale further research is necessary on the antigenic structure of Neisseria gonorrhoeae, and other organisms of the Neisseria group, before reliance can be placed on the strict specificity of this test.
The author also describes the fluorescent antibody technique for gonorrhoea used in the USSR, discussing its advantages and disadvantages.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOREL L. J., DUREL P. [Immuno-fluorescence applied to the diagnosis of syphilis]. Pathol Biol. 1959 Nov;7:2317–2324. [PubMed] [Google Scholar]
- Boor A. K., Miller C. P. A STUDY ON BACTERIAL PROTEINS WITH SPECIAL CONSIDERATION OF GONOCOCCUS AND MENINGOCOCCUS. J Exp Med. 1934 Jan 1;59(1):63–74. doi: 10.1084/jem.59.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COONS A. H., KAPLAN M. H. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. J Exp Med. 1950 Jan 1;91(1):1–13. doi: 10.1084/jem.91.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DEACON W. E., FALCONE V. H., HARRIS A. A fluorescent test for treponemal antibodies. Proc Soc Exp Biol Med. 1957 Nov;96(2):477–480. doi: 10.3181/00379727-96-23512. [DOI] [PubMed] [Google Scholar]
- DEACON W. E., PEACOCK W. L., Jr, FREEMAN E. M., HARRIS A., BUNCH W. L., Jr Fluorescent antibody tests for detection of the gonococcus in women. Public Health Rep. 1960 Feb;75:125–129. [PMC free article] [PubMed] [Google Scholar]
- HARRIS A., BOSSAK H. M., DEACON W. E., BUNCH W. L., Jr Comparison of the fluorescent treponemal antibody test with other tests for syphilis on cerebrospinal fluids. Br J Vener Dis. 1960 Sep;36:178–180. doi: 10.1136/sti.36.3.178. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILSON J. F. A serological study of Neisseria gonorrhoeae. J Pathol Bacteriol. 1954 Oct;68(2):495–510. doi: 10.1002/path.1700680222. [DOI] [PubMed] [Google Scholar]
- WILSON J. F. A serological study of the Meningococcus. J Pathol Bacteriol. 1956 Jul;72(1):111–119. doi: 10.1002/path.1700720115. [DOI] [PubMed] [Google Scholar]