Abstract
As part of a collaborative assay of the proposed Fifth International Standard for Gas-Gangrene Antitoxin (Perfringens), five ampoules of the proposed replacement material were assayed in the authors' laboratory against the then current Fourth International Standard. Both in vitro and in vivo methods were used. This paper presents the results and their statistical analysis.
The two methods yielded different results which were not likely to have been due to chance, but exact statistical comparison is not possible. It is thought, however, that the differences may be due, at least in part, to differences in the relative proportions of zeta-antitoxin and alpha-antitoxin in the Fourth and Fifth International Standards and the consequent different reactions with the test toxin that was used for titration.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- EVANS D. G., PERKINS F. T. FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS) (CLOSTRIDIUM WELCHII TYPE A ANTITOXIN). Bull World Health Organ. 1963;29:729–735. [PMC free article] [PubMed] [Google Scholar]