Abstract
In view of the fact that diaphenylsulfone has been shown to have low schizontocidal activity against Plasmodium gallinaceum and to lead to resistance in strains of P. cynomolgi, investigations were undertaken into the joint action of diaphenylsulfone and pyrimethamine against P. gallinaceum in chicks and P. cynomolgi bastianellii in monkeys. These drugs were assayed separately and in various combinations. It was found that at certain dose levels combination of the two drugs led to potentiation of their plasmocidal activity. On the other hand, this synergistic effect was not noted with combinations containing lower dosages of either drug; with these, a simple additive effect occurred. The authors suggest that the two drugs probably act on the same metabolic pathway but that their points of attack may be different. They note also that there was a difference in the response of P. gallinaceum in chicks and of P. cynomolgi bastianellii in monkeys to the combined use of the two drugs.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ARCHIBALD H. M., ROSS C. M. A preliminary report on the effect of diamino-diphenyl sulphone on malaria in northern Nigeria. J Trop Med Hyg. 1960 Feb;63:25–27. [PubMed] [Google Scholar]
- HURLY M. G. Potentiation of pyrimethamine by sulphadiazine in human malaria. Trans R Soc Trop Med Hyg. 1959 Sep;53:412–413. doi: 10.1016/0035-9203(59)90044-6. [DOI] [PubMed] [Google Scholar]
- JASWANT SINGH, BASU P. C., RAY A. P. Screening of antimalarials against P. gallinaceum in chicks. Indian J Malariol. 1952 Jun;6(2):145–158. [PubMed] [Google Scholar]
- RAMAKRISHNAN S. P., BASU P. C., SINGH H., SINGH N. Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria. Bull World Health Organ. 1962;27:213–221. [PMC free article] [PubMed] [Google Scholar]
- ROLLO I. M. The mode of action of sulphonamides, proguanil and pyrimethamine on Plasmodium gallinaceum. Br J Pharmacol Chemother. 1955 Jun;10(2):208–214. doi: 10.1111/j.1476-5381.1955.tb00084.x. [DOI] [PMC free article] [PubMed] [Google Scholar]