Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1965;32(1):29–36.

The present status of field and laboratory studies of typhoid and paratyphoid vaccines

With special reference to studies sponsored by the World Health Organization

B Cvjetanović, K Uemura
PMCID: PMC2555191  PMID: 14290077

Abstract

The authors present a summary of the information yielded by a number of collaborative field and laboratory studies of typhoid vaccines conducted under the auspices of the World Health Organization, comparing, in particular, the results of various controlled field trials carried out in British Guiana, Poland, the USSR and Yugoslavia, and attempting to evaluate the effectiveness of the vaccines in man.

Acetone-inactivated typhoid vaccine, which has been established as an international reference preparation, has been proved in field trials to be of a high degree of effectiveness and to confer protection of long duration.

Comparison of the results of the field trials with those of laboratory studies indicate that further research is needed in order to develop a test or tests the results of which can be fully correlated with the effectiveness of typhoid vaccines as demonstrated in man.

Reference is also made to field studies of paratyphoid vaccines.

Full text

PDF
29

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENENSON A. S. SEROLOGICAL RESPONSES OF MAN TO TYPHOID VACCINES. Bull World Health Organ. 1964;30:653–662. [PMC free article] [PubMed] [Google Scholar]
  2. EDSALL G., CARLSON M. C., FORMAL S. B., BENENSON A. S. Laboratory tests of typhoid vaccines used in a controlled field study. Bull World Health Organ. 1959;20:1017–1032. [PMC free article] [PubMed] [Google Scholar]
  3. FISEK N. H., GOREN S., AKYAY N. Mouse challenge with Salmonella typhosa T 5501 in testing the potency of typhoid vaccines. Bull World Health Organ. 1959;20:1257–1259. [PMC free article] [PubMed] [Google Scholar]
  4. HEJFEC L. B. RESULTS OF THE STUDY OF TYPHOID VACCINES IN FOUR CONTROLLED FIELD TRIALS IN THE USSR. Bull World Health Organ. 1965;32:1–14. [PMC free article] [PubMed] [Google Scholar]
  5. KHASANOV M. I., KHEIFETS L. B., SALMIN L. V. A controlled field trial of the typhoid component of polyvalent enteric vaccine (NIISI polyvaccine). Bull World Health Organ. 1962;26:371–379. [PMC free article] [PubMed] [Google Scholar]
  6. SPAUN J., UEMURA K. INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES. Bull World Health Organ. 1964;31:761–791. [PMC free article] [PubMed] [Google Scholar]
  7. STANDFAST A. F. A report on the laboratory assays carried out at the Lister Institute of Preventive Medicine on the typhoid vaccines used in the field study in Yugoslavia. Bull World Health Organ. 1960;23:37–45. [PMC free article] [PubMed] [Google Scholar]
  8. STANDFAST A. F. Experiments with Vi-negative strains of Salmonella typhi. Bull World Health Organ. 1960;23:47–52. [PMC free article] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES