Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1965;32(1):37–45.

Laboratory tests on the effectiveness of oral vaccination of young children against typhoid and paratyphoid A and B

I R Vlădoianu, G Dimache, S Antohi, Constanța Vlădoianu, Ortansa Zarma
PMCID: PMC2555198  PMID: 14290078

Abstract

In Romania, pre-school children are excluded from subcutaneous inoculation with typhoid and paratyphoid A and B vaccine. The authors have therefore investigated the possibility of giving them an oral vaccine. Laboratory tests were carried out on 30 children from 3 to 7 years of age. Samples of blood serum were collected before and after vaccination and subsequently tested for (1) seroprotection in chick embryos, (2) seroprotection in white mice, (3) titration of the agglutinating antibodies, and (4) electrophoretic pattern.

The results obtained showed that the oral administration of the vaccine can, under the conditions used in the test, afford a considerable degree of protection to young children.

Full text

PDF
37

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENZONI G. Su di un nuovo tipo di vaccino antitifico per via orale sterilizzato con l'acetone. Boll Ist Sieroter Milan. 1953 Nov-Dec;32(11-12):463–469. [PubMed] [Google Scholar]
  2. BERNARD J. G., COLOBERT L., DARBON A., DIOUX R., DOUKHAN G., GIRIER L., MONTAGNON B., SERVANT P. [Immunological study of combined antidiphtheritic, antitetanic, antityphoparatyphoid and antipoliomyelitic vaccinaction]. Bull World Health Organ. 1962;26:699–725. [PMC free article] [PubMed] [Google Scholar]
  3. BONET-MAURY P., JUDE A., SERVANT P. La mesure statistique de la virulence et de l'immunité: application a l'étude de la virulence du bacille typhique et a la mesure du pouvoir immunisant des vaccins antityphoidiques. Rev Immunol Ther Antimicrob. 1954;18(1-2):21–49. [PubMed] [Google Scholar]
  4. COLOBERT L., KIRN A., SERVANT P., MONTAGNON B. [Lytic properties of the serum. III. Influence in the monkey of antityphoparatyphoid vaccination on obsistin content]. Ann Inst Pasteur (Paris) 1961 May;100:600–612. [PubMed] [Google Scholar]
  5. COLOBERT L., KIRN A. [The lytic properties of normal serum. II. GObsistin and Vi antigen of Eberthella typhi]. Ann Inst Pasteur (Paris) 1961 Feb;100:159–165. [PubMed] [Google Scholar]
  6. GRABAR J., LE MINOR S. Test de séroprotection antityphoïdique sur l'embryon de poulet. Ann Inst Pasteur (Paris) 1951 Nov;81(5):528–540. [PubMed] [Google Scholar]
  7. LITCHFIELD J. T., Jr, WILCOXON F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther. 1949 Jun;96(2):99–113. [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES