Abstract
The antigenic structure of eight strains of influenza A viruses of avian origin was investigated by haemagglutination inhibition, virus neutralization and strain-specific complement fixation. All strains could be distinguished from each other, but certain cross-reactions were observed allowing the establishment of four antigenic groupings, as follows: (1) classic fowl plague virus (“Dutch” strain), Turkey/England/63 (“Langham” strain) and virus N; (2) two strains isolated from ducks, one in Czechoslovakia in 1956 and one in England in 1962; (3) a third strain isolated from ducks in England in 1956; (4) the “Smith” strain (Chicken/Scotland/59) and the tern virus (Tern/South Africa/61).
This article also reports the results of tests to determine the capacity of the above-mentioned viruses to infect monkey-kidney cultures and to produce plaques in chick-embryo fibroblasts. It concludes with a discussion of problems connected with the classification and nomenclature of these viruses.
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- LIFE F. S., HENLE W. Methods and procedures for use of complement-fixation technique in type- and strain-specific diagnosis of influenza. Bull World Health Organ. 1959;20(2-3):411–420. [PMC free article] [PubMed] [Google Scholar]
- MORGAN J. F., MORTON H. J., PARKER R. C. Nutrition of animal cells in tissue culture; initial studies on a synthetic medium. Proc Soc Exp Biol Med. 1950 Jan;73(1):1–8. doi: 10.3181/00379727-73-17557. [DOI] [PubMed] [Google Scholar]
- PEREIRA H. G., PEREIRA M. S., LAW V. G. ANTIGENIC VARIANTS OF INFLUENZA A2 VIRUS. Bull World Health Organ. 1964;31:129–132. [PMC free article] [PubMed] [Google Scholar]
- PORTERFIELD J. S. A simple plaque-inhibition test for the study of arthropod-borne viruses. Bull World Health Organ. 1960;22:373–380. [PMC free article] [PubMed] [Google Scholar]
- VOGEL J., SHELOKOV A. Adsorption-hemagglutination test for influenza virus in monkey kidney tissue culture. Science. 1957 Aug 23;126(3269):358–359. doi: 10.1126/science.126.3269.358-a. [DOI] [PubMed] [Google Scholar]