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. 1961;25(1):103–114.

Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non-exposed persons

Part 3*

P Atanasiu, D A Cannon, D J Dean, J P Fox, K Habel, M M Kaplan, R E Kissling, H Koprowski, P Lépine, F Pérez Gallardo
PMCID: PMC2555550  PMID: 13863061

Abstract

This study is the third in a series on virus-neutralizing antibody response to different schedules of antirabies serum and vaccines in previously non-exposed persons. Three types of vaccine were studied—phenolized (Semple), duck embryo and high-egg-passage (HEP) chicken embryo. Reduced schedules of vaccine, consisting of 2-7 inoculations given at various intervals, did not give results comparable in efficacy (time of appearance, level and persistence of antibody) with schedules comprising at least 14 daily inoculations of vaccine as determined in previous trials. The effectiveness of a booster dose in previously sensitized individuals was confirmed with a demonstration that a rise in serum antibody appears between 4 and 8 days after the booster inoculation. Effective sensitization appears to be as much a function of spacing of inoculations as of total dosage of vaccine antigen. Interference by immune serum with the antigenicity of subsequently administered vaccine, noted previously by the present authors and by other workers, was again confirmed. This interference could be overcome by the administration of a sufficient amount of vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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