Abstract
By use of monoclonal antibodies cross-reactive with Marek's disease virus and herpesvirus of turkeys, three glycoproteins (for Marek's disease virus, gp115/110, gp63, and gp50; for herpesvirus of turkeys, gp115, gp62 and gp52) related to virus neutralization were identified. Immunization of chickens or rabbits with these glycoproteins purified by affinity chromatography resulted in production of neutralizing antibodies.
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- Churchill A. E., Chubb R. C., Baxendale W. The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture. J Gen Virol. 1969 Jun;4(4):557–564. doi: 10.1099/0022-1317-4-4-557. [DOI] [PubMed] [Google Scholar]
- Goding J. W. Use of staphylococcal protein A as an immunological reagent. J Immunol Methods. 1978;20:241–253. doi: 10.1016/0022-1759(78)90259-4. [DOI] [PubMed] [Google Scholar]
- Hirai K., Ikuta K., Kato S. Comparative studies on Marek's disease virus and herpesvirus of turkey DNAs. J Gen Virol. 1979 Oct;45(1):119–131. doi: 10.1099/0022-1317-45-1-119. [DOI] [PubMed] [Google Scholar]
- Ikuta K., Honma H., Maotani K., Ueda S., Kato S., Hirai K. Monoclonal antibodies specific to and cross-reactive with Marek's disease virus and herpesvirus of turkeys. Biken J. 1982 Dec;25(4):171–175. [PubMed] [Google Scholar]
- Ikuta K., Nishi Y., Kato S., Hirai K. Immunoprecipitation of Marek's disease virus-specific polypeptides with chicken antibodies purified by affinity chromatography. Virology. 1981 Oct 15;114(1):277–281. doi: 10.1016/0042-6822(81)90277-4. [DOI] [PubMed] [Google Scholar]
- Ikuta K., Ueda S., Kato S., Hirai K. Most virus-specific polypeptides in cells productively infected with Marek's disease virus or herpesvirus of turkeys possess cross-reactive determinants. J Gen Virol. 1983 Apr;64(Pt 4):961–965. doi: 10.1099/0022-1317-64-4-961. [DOI] [PubMed] [Google Scholar]
- Kaschka-Dierich C., Bornkamm G. W., Thomssen R. No homology detectable between Marek's disease virus (MDV) DNA and herpesvirus of the turkey (HVT) DNA. Med Microbiol Immunol. 1979 Jan 24;165(4):223–239. doi: 10.1007/BF02152922. [DOI] [PubMed] [Google Scholar]
- Lee L. F., Liu X., Witter R. L. Monoclonal antibodies with specificity for three different serotypes of Marek's disease viruses in chickens. J Immunol. 1983 Feb;130(2):1003–1006. [PubMed] [Google Scholar]
- Lee Y. S., Tanaka A., Silver S., Smith M., Nonoyama M. Minor DNA homology between herpesvirus of turkey and Marek's disease virus? Virology. 1979 Feb;93(1):277–280. doi: 10.1016/0042-6822(79)90299-x. [DOI] [PubMed] [Google Scholar]
- Onuma M., Mikami T., Hayashi T. T., Okada K., Fujimoto Y. Studies of Marek's disease herpesvirus and turkey herpesvirus specific common antigen which stimulates the production of neutralizing antibodies. Arch Virol. 1975;48(1):85–97. doi: 10.1007/BF01320568. [DOI] [PubMed] [Google Scholar]
- Onuma M., Mikami T., Hayashi T. T. Properties of the common antigen associated with Marek's disease herpesvirus and turkey herpesvirus infections. J Natl Cancer Inst. 1974 Mar;52(3):805–813. doi: 10.1093/jnci/52.3.805. [DOI] [PubMed] [Google Scholar]
- Purchase H. G. Immunofluorescence in the study of Marek's disease. I. Detection of antigen in cell culture and an antigenic comparison of eight isolates. J Virol. 1969 Jun;3(6):557–565. doi: 10.1128/jvi.3.6.557-565.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ross L. J., Biggs P. M., Newton A. A. Purification and properties of the 'A' antigen associated with Marek's disease virus infections. J Gen Virol. 1973 Mar;18(3):291–304. doi: 10.1099/0022-1317-18-3-291. [DOI] [PubMed] [Google Scholar]
- Volk W. A., Synder R. M., Benjamin D. C., Wagner R. R. Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity. J Virol. 1982 Apr;42(1):220–227. doi: 10.1128/jvi.42.1.220-227.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Witter R. L., Nazerian K., Purchase H. G., Burgoyne G. H. Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. Am J Vet Res. 1970 Mar;31(3):525–538. [PubMed] [Google Scholar]
- Wyn-Jones A. P., Kaaden O. R. Induction of virus-neutralizing antibody by glycoproteins isolated from chicken cells infected with a herpesvirus of turkeys. Infect Immun. 1979 Jul;25(1):54–59. doi: 10.1128/iai.25.1.54-59.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]