Abstract
In view of doubts as to the potency level required to obtain nearly 100% successful vaccinations with the glycerolated smallpox vaccine prepared by the Netherlands National Institute of Public Health, its dose-effect relationship was compared with that of a glycerolated lymph from the Lister Institute of Preventive Medicine, England. The potency was estimated from pock counts on the chorio-allantoic membrane of chick embryos and the effect was judged from the ”take” rate obtained in the primary vaccination of soldiers, the data being subjected to probit analysis.
The relationship observed between the number of pock-forming units and the percentage of successful primary vaccinations was nearly identical with the two vaccines. The 50% effective doses were found to be 1.3-1.4 × 106 PFU/ml and the 99% doses to be 4.1-4.3 × 107 PFU/ml.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COCKBURN W. C., CROSS R. M., DOWNIE A. W., DUMBELL K. R., KAPLAN C., MCCLEAN D., PAYNE A. M. Laboratory and vaccination studies with dried smallpox vaccines. Bull World Health Organ. 1957;16(1):63–77. [PMC free article] [PubMed] [Google Scholar]
- CROSS R. M., KAPLAN C., McCLEAN D. Studies with dried and glycerinated smallpox vaccines of full and diminished potencies. Bull World Health Organ. 1958;19(1):123–128. [PMC free article] [PubMed] [Google Scholar]
- GISPEN R., LANSBERG H. P., NANNING W. The effect of antivaccinia gamma globulin on smallpox vaccination in view of a proposed attempt to prevent postvaccinal encephalitis. Antonie Van Leeuwenhoek. 1956;22(1):89–102. doi: 10.1007/BF02538316. [DOI] [PubMed] [Google Scholar]