Abstract
The state of pregnancy was associated with a marked enhancement of both proliferative and cytotoxic T cell antiviral immune responses after infection of mice with avirulent Semliki Forest virus. Strong responses were obtained from the spleen and the para-aortic lymph nodes that drain the uterus. This immune enhancement seemed to be in response to the increased antigenic challenge that originated from infected placental and fetal tissue and was released during the process of abortion. Immune enhancement was not observed in pregnant mice similarly infected with Ross River virus, which also established an intrauterine infection but does not cause abortion.
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Selected References
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- Aaskov J. G., Davies C. E., Tucker M., Dalglish D. Effect on mice of infection during pregnancy with three Australian arboviruses. Am J Trop Med Hyg. 1981 Jan;30(1):198–203. doi: 10.4269/ajtmh.1981.30.198. [DOI] [PubMed] [Google Scholar]
- Anderson D. J. The responsiveness of various maternal mouse lymphocyte populations to mitogenic stimulation in vitro. Cell Immunol. 1978 Nov;41(1):150–156. doi: 10.1016/s0008-8749(78)80034-3. [DOI] [PubMed] [Google Scholar]
- Atkins G. J., Carter J., Sheahan B. J. Effect of alphavirus infection on mouse embryos. Infect Immun. 1982 Dec;38(3):1285–1290. doi: 10.1128/iai.38.3.1285-1290.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Birkeland S. A., Teisner B., Schilling W., Kemp E., Pedersen G. T., Svehag S. E. Effect of pregnancy zone protein on leucocyte migration inhibition, lymphoycte transformation and rosette formation by lymphocytes. Acta Pathol Microbiol Scand C. 1979 Jun;87C(3):235–240. [PubMed] [Google Scholar]
- Clark D. A., McDermott M. R. Active suppression of host-vs-graft reaction in pregnant mice. III. Developmental kinetics, properties, and mechanism of induction of suppressor cells during first pregnancy. J Immunol. 1981 Oct;127(4):1267–1273. [PubMed] [Google Scholar]
- Griffin D. E., Johnson R. T. Cellular immune response to viral infection: in vitro studies of lymphocytes from mice infected with Sindbis virus. Cell Immunol. 1973 Dec;9(3):426–434. doi: 10.1016/0008-8749(73)90057-9. [DOI] [PubMed] [Google Scholar]
- Hagen C., Froland A. Depressed lymphocyte response to P.H.A. in women taking oral contraceptives. Lancet. 1972 May 27;1(7761):1185–1185. doi: 10.1016/s0140-6736(72)91415-8. [DOI] [PubMed] [Google Scholar]
- Hapel A. J. The protective role of thymus-derived lymphocytes in arbovirus-induced meningoencephalitis. Scand J Immunol. 1975;4(3):267–278. doi: 10.1111/j.1365-3083.1975.tb02626.x. [DOI] [PubMed] [Google Scholar]
- Hill C. A., Finn R., Denye V. Depression of cellular immunity in pregnancy due to a serum factor. Br Med J. 1973 Sep 8;3(5879):513–514. doi: 10.1136/bmj.3.5879.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Milner A. R., Marshall I. D. Pathogenesis of in utero infections with abortogenic and non-abortogenic alphaviruses in mice. J Virol. 1984 Apr;50(1):66–72. doi: 10.1128/jvi.50.1.66-72.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Müllbacher A. Neonatal tolerance to alloantigens alters major histocompatibility complex-restricted response patterns. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7689–7691. doi: 10.1073/pnas.78.12.7689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nossal G. J., Abbot A., Mitchell J., Lummus Z. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med. 1968 Feb 1;127(2):277–290. doi: 10.1084/jem.127.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siiteri P. K., Stites D. P. Immunologic and endocrine interrelationships in pregnancy. Biol Reprod. 1982 Feb;26(1):1–14. doi: 10.1095/biolreprod26.1.1. [DOI] [PubMed] [Google Scholar]