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. 1962;27(4-5):555–568.

A review of progress in the chemotherapy and control of filariasis since 1955*

F Hawking
PMCID: PMC2555874  PMID: 13953210

Abstract

There has been little change since 1955 in the laboratory techniques for seeking new antifilarial compounds, although one valuable addition to laboratory study has been the experimental infection of cats with Brugia malayi.

The chief drug for the treatment and control of filariasis—whether caused by Wuchereria bancrofti or by B. malayi—continues to be diethylcarbamazine, and the author reviews the reports recently published on its use. In India and China large-scale campaigns involving the use of this drug have been undertaken; and in Tahiti filariasis has been suppressed and almost eliminated. Campaigns on a smaller scale and pilot projects considered in this survey include those conducted in Pacific islands, Malaya, Ceylon, Brazil, Surinam and East and West Africa.

It is generally agreed that the administration of diethylcarbamazine produces a great diminution in the microfilarial counts of those taking it, and in many persons both microfilariae and adult worms are eradicated. The difficulties which arise are due to toxic effects which occur in some recipients and which may adversely affect the acceptability of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNETT G. F., MATAIKA J. U. Mass-administration of diethylcarbamazine citrate in preventing transmission of aperiodic human filariasis. Trans R Soc Trop Med Hyg. 1961 Mar;55:178–187. doi: 10.1016/0035-9203(61)90023-2. [DOI] [PubMed] [Google Scholar]
  2. EDESON J. F., LAING A. B. Studies on filariasis in Malaya: the effect of diethylcarbamazine on Brugia malayi and B. pahangi in domestic cats. Ann Trop Med Parasitol. 1959 Dec;53:394–399. doi: 10.1080/00034983.1959.11685938. [DOI] [PubMed] [Google Scholar]
  3. EDESON J. F., WHARTON R. H. Studies on filariasis in Malaya: treatment of Wuchereria malayi-carriers with monthly or weekly doses of diethylcarbamazine (banocide). Ann Trop Med Parasitol. 1958 Mar;52(1):87–92. doi: 10.1080/00034983.1958.11685849. [DOI] [PubMed] [Google Scholar]
  4. FRIEDHEIM E. A., de JONGH R. [The effect of pentylthiarsaphenylmelamine (Mel W) on Wucheria bancrofti]. Bull Soc Pathol Exot Filiales. 1959 Nov-Dec;52:785–791. [PubMed] [Google Scholar]
  5. HASSAN M. Y. The filariasis campaign in Kedah. Med J Malaya. 1959 Sep;14:36–46. [PubMed] [Google Scholar]
  6. HAWKING F. Some recent work on filariasis. Trans R Soc Trop Med Hyg. 1950 Sep;44(2):153–192. doi: 10.1016/0035-9203(50)90044-7. [DOI] [PubMed] [Google Scholar]
  7. HAWKING F., TERRY R. J. Chemotherapeutic properties of some new quaternary ammonium salts. II. Antifilarial action against Litomosoides carini. J Pharm Pharmacol. 1959 Feb;11(2):94–98. doi: 10.1111/j.2042-7158.1959.tb12530.x. [DOI] [PubMed] [Google Scholar]
  8. HEISCH R. B., NELSON G. S., FURLONG M. Studies in filariasis in East Africa. 1. Filariasis on the Island of Pate, Kenya. Trans R Soc Trop Med Hyg. 1959 Jan;53(1):41–53. doi: 10.1016/0035-9203(59)90082-3. [DOI] [PubMed] [Google Scholar]
  9. JORDAN P. A pilot scheme to eradicate bancroftian filariasis with diethylcarbamazine; results of the first year's treatment. Trans R Soc Trop Med Hyg. 1959 Jan;53(1):54–60. doi: 10.1016/0035-9203(59)90083-5. [DOI] [PubMed] [Google Scholar]
  10. KESSEL J. F. An effective programme for the control of filariasis in Tahiti. Bull World Health Organ. 1957;16(3):633–664. [PMC free article] [PubMed] [Google Scholar]
  11. LAIGRET J., VOISIN H. La notezine estelle un emménagogue? Med Trop (Mars) 1958 Jul-Aug;18(4):689–693. [PubMed] [Google Scholar]
  12. MARCH H. N., LAIGRET J., KESSEL J. F., BAMBRIDGE B. Reduction in the prevalence of clinical filariasis in Tahiti following adoption of a control program. Am J Trop Med Hyg. 1960 Mar;9:180–184. doi: 10.4269/ajtmh.1960.9.180. [DOI] [PubMed] [Google Scholar]
  13. MCGREGOR I. A., GILLES H. M. Diethylcarbamazine control of bancroftian filariasis; follow-up of a field trial in West Africa. Br Med J. 1956 Feb 11;1(4962):331–332. doi: 10.1136/bmj.1.4962.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MCGREGOR I. A., HAWKING F., SMITH D. A. The control of filariasis with hetrazan; a field trial in a rural village (Keneba) in the Gambia. Br Med J. 1952 Oct 25;2(4790):908–911. doi: 10.1136/bmj.2.4790.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. NELSON G. S., GROUNDS J. G. Onchocerciasis at Kodera eleven years after the eradication of the vector. East Afr Med J. 1958 Jul;35(7):365–368. [PubMed] [Google Scholar]
  16. Otto G. F., Maren T. H. Filaricidal Activity of Substituted Phenyl Arsenoxides. Science. 1947 Aug 1;106(2744):105–107. doi: 10.1126/science.106.2744.105. [DOI] [PubMed] [Google Scholar]
  17. SASA M., HAYASHI S., SATO K., IKESHOJI T., TANAKA H. A review of field experiments in the control of bancroftian and malayan filariasis in Japan, 1958. Jpn J Exp Med. 1959 Oct;29:369–405. [PubMed] [Google Scholar]
  18. SIMPSON E. J. Mass therapy in filariasis: a note on control in Niue Island. N Z Med J. 1957 Apr;56(312):136–137. [PubMed] [Google Scholar]
  19. SYMES C. B. Observations on the epidemiology of filariasis in Fiji. J Trop Med Hyg. 1960 Mar;63:59–67. [PubMed] [Google Scholar]
  20. TURNER L. H., SODHY L. S. Studies on filariasis in Malaya: a trial mass treatment of Wuchereria malayi filariasis with single daily doses of diethylcarbamazine. Ann Trop Med Parasitol. 1959 Sep;53:268–273. doi: 10.1080/00034983.1959.11685924. [DOI] [PubMed] [Google Scholar]
  21. TURNER L. H. Studies on filariasis in Malaya: treatment of Wuchereria malayi filariasis with diethylcarbamazine in single daily doses. Ann Trop Med Parasitol. 1959 Jun;53:180–188. doi: 10.1080/00034983.1959.11685915. [DOI] [PubMed] [Google Scholar]
  22. WHARTON R. H., EDESON J. F., WILSON T., REID J. A. Studies on filariasis in Malaya: pilot experiments in the control of filariasis due to Wuchereria malayi in East Pahang. Ann Trop Med Parasitol. 1958 Jul;52(2):191–205. doi: 10.1080/00034983.1958.11685861. [DOI] [PubMed] [Google Scholar]
  23. WHARTON R. H. Studies on filariasis in Malaya: the efficiency of Mansonia longipalpis as an experimental vector of Wuchereria malayi. Ann Trop Med Parasitol. 1957 Dec;51(4):422–439. doi: 10.1080/00034983.1957.11685832. [DOI] [PubMed] [Google Scholar]

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