Table 3.
Results of univariate and multivariate analyses of graft and patient factors influencing platelet engraftment
| Variable | Univariate analysis (includes only significant variables) |
Multivariate analysis (includes only significant variables) |
Favorable in multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | ||
| Age, y | |||||||
| Older than 2 | 0.46 | 0.31-0.67 | < .001 | 0.57 | 0.38-0.85 | < .01 | Patients ≤ 2 y |
| 2 or younger | 1.00 | 1.00 | |||||
| Recipient sex | |||||||
| Male | 0.64 | 0.45-0.93 | .02 | 0.65 | 0.44-0.95 | .03 | Female recipients |
| Female | 1.00 | 1.00 | |||||
| Cryopreserved cell dose, × 107/kg | |||||||
| More than 9.7 | 1.58 | 1.10-2.28 | .01 | ||||
| 9.7 or less | 1.00 | ||||||
| Reinfused cell dose, × 107/kg | |||||||
| More than 7.6 | 1.85 | 1.28-2.66 | < .01 | ||||
| 7.6 or less | 1.00 | ||||||
| Reinfused CD34, × 105/kg | |||||||
| More than 2.1 | 1.49 | 1.04-2.15 | .03 | ||||
| 2.1 or less | 1.00 | ||||||
| Reinfused CFU, × 104/kg | |||||||
| More than 5.7 | 3.42 | 2.33-5.02 | < .001 | 2.81 | 1.87-4.21 | < .001 | Higher CFU infused |
| 5.7 or less | 1.00 | 1.00 | |||||
| Reinfused CD3, × 106/kg | |||||||
| More than 14.2 | 1.45 | 1.01-2.09 | .05 | ||||
| 14.2 or less | 1.00 | ||||||
| ABO match | |||||||
| Mismatched | 1.47 | 1.02-2.13 | .04 | ||||
| Matched | 1.00 | ||||||
Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), unit sex, sex matching (recipient/unit), date of transplantation (after 1/1/2001, before 1/1/2001), HLA match (3/6 and 4/6 versus 5/6 and 6/6), recipient ethnicity, unit ethnicity, ethnicity matching (recipient/unit), recipient CMV status, and recipient weight (<12 kg, ≥ 12 kg).