Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1984 May;50(2):662–665. doi: 10.1128/jvi.50.2.662-665.1984

Deletion of DNA sequence in a nononcogenic variant of Herpesvirus saimiri.

J M Koomey, C Mulder, R L Burghoff, B Fleckenstein, R C Desrosiers
PMCID: PMC255703  PMID: 6323769

Abstract

The 110-kilobase-pair stretch of unique sequence DNA of Herpesvirus saimiri is flanked by highly repetitive DNA. Detailed restriction endonuclease mapping has localized the left junction of repetitive and unique DNA to a 100-base-pair region. H. saimiri 11att, a replication competent nononcogenic variant of strain 11, has a deletion of 2.3 kilobase pairs of sequence information that spans this left junction of repetitive and unique DNA.

Full text

PDF
662

Images in this article

663Image
on p.663

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bishop J. M. Cellular oncogenes and retroviruses. Annu Rev Biochem. 1983;52:301–354. doi: 10.1146/annurev.bi.52.070183.001505. [DOI] [PubMed] [Google Scholar]
  2. Bornkamm G. W., Delius H., Fleckenstein B., Werner F. J., Mulder C. Structure of Herpesvirus saimiri genomes: arrangement of heavy and light sequences in the M genome. J Virol. 1976 Jul;19(1):154–161. doi: 10.1128/jvi.19.1.154-161.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Desrosiers R. C., Burghoff R. L., Bakker A., Kamine J. Construction of replication-competent Herpesvirus saimiri deletion mutants. J Virol. 1984 Feb;49(2):343–348. doi: 10.1128/jvi.49.2.343-348.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Desrosiers R. C., Falk L. A. Herpesvirus saimiri strain variability. J Virol. 1982 Jul;43(1):352–356. doi: 10.1128/jvi.43.1.352-356.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Desrosiers R. C. Herpesvirus saimiri DNA in tumor cells--deleted sequences and sequence rearrangements. J Virol. 1981 Aug;39(2):497–509. doi: 10.1128/jvi.39.2.497-509.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Desrosiers R. C. Specifically unmethylated cytidylic-guanylate sites in Herpesvirus saimiri DNA in tumor cells. J Virol. 1982 Aug;43(2):427–435. doi: 10.1128/jvi.43.2.427-435.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Falk L., Schaffer P., Wright J., Deinhardt F., Wolfe L., Benyesh-Melnick M. Experimental infection of marmoset and squirrel monkeys with attenuated HVS. Bibl Haematol. 1975 Oct;(43):336–338. doi: 10.1159/000399160. [DOI] [PubMed] [Google Scholar]
  8. Falk L., Wright J., Deinhardt F., Wolfe L., Schaffer P., Benyesh-Melnick M. Experimental infection of squirrel and marmoset monkeys with attenuated Herpesvirus saimiri. Cancer Res. 1976 Feb;36(2 Pt 2):707–710. [PubMed] [Google Scholar]
  9. Galloway D. A., McDougall J. K. The oncogenic potential of herpes simplex viruses: evidence for a 'hit-and-run' mechanism. Nature. 1983 Mar 3;302(5903):21–24. doi: 10.1038/302021a0. [DOI] [PubMed] [Google Scholar]
  10. Grunstein M., Wallis J. Colony hybridization. Methods Enzymol. 1979;68:379–389. doi: 10.1016/0076-6879(79)68027-8. [DOI] [PubMed] [Google Scholar]
  11. Hayward W. S., Neel B. G., Astrin S. M. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature. 1981 Apr 9;290(5806):475–480. doi: 10.1038/290475a0. [DOI] [PubMed] [Google Scholar]
  12. Kaschka-Dierich C., Werner F. J., Bauer I., Fleckenstein B. Structure of nonintegrated, circular Herpesvirus saimiri and Herpesvirus ateles genomes in tumor cell lines and in vitro-transformed cells. J Virol. 1982 Oct;44(1):295–310. doi: 10.1128/jvi.44.1.295-310.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nelson J. A., Fleckenstein B., Galloway D. A., McDougall J. K. Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169. J Virol. 1982 Jul;43(1):83–91. doi: 10.1128/jvi.43.1.83-91.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Payne G. S., Bishop J. M., Varmus H. E. Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature. 1982 Jan 21;295(5846):209–214. doi: 10.1038/295209a0. [DOI] [PubMed] [Google Scholar]
  15. Schaffer P. A., Falk L. A., Deinhardt F. Attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees C. J Natl Cancer Inst. 1975 Nov;55(5):1243–1246. doi: 10.1093/jnci/55.5.1243. [DOI] [PubMed] [Google Scholar]
  16. Schirm S., Müller I., Desrosiers R. C., Fleckenstein B. Herpesvirus saimiri DNA in a lymphoid cell line established by in vitro transformation. J Virol. 1984 Mar;49(3):938–946. doi: 10.1128/jvi.49.3.938-946.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wright J., Falk L. A., Wolfe L. G., Deinhardt F. Herpesvirus saimiri: protective effect of attenuated strain against lymphoma induction. Int J Cancer. 1980 Oct 15;26(4):477–482. doi: 10.1002/ijc.2910260413. [DOI] [PubMed] [Google Scholar]
  18. Wright J., Falk L. A., Wolfe L. G., Ogden J., Deinhardt F. Susceptibility of common marmosets (Callithrix jacchus) to oncogenic and attenuated strains of Herpesvirus saimiri. J Natl Cancer Inst. 1977 Nov;59(5):1475–1478. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES