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. 1987 Aug;61(8):2639–2641. doi: 10.1128/jvi.61.8.2639-2641.1987

Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus.

J W Gnann Jr, J A Nelson, M B Oldstone
PMCID: PMC255715  PMID: 2439707

Abstract

Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

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Selected References

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