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. 1984 Jun;50(3):951–953. doi: 10.1128/jvi.50.3.951-953.1984

Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity.

R C Kennedy, K Adler-Storthz, J W Burns Sr, R D Henkel, G R Dreesman
PMCID: PMC255759  PMID: 6202879

Abstract

Antiidiotype reagents that recognize idiotypic determinants associated with the combining site of monoclonal antibodies to herpes simplex virus type 2 ( HSV2 ) were used to manipulate the immune response to HSV2 in BALB/c mice. The injection of antiidiotype antibodies into mice before challenge with a 50% lethal dose of HSV2 resulted in a shorter survival time than that of mice receiving either preimmune rabbit immunoglobulin G or antiidiotype reagents against hepatitis B surface antigen before HSV2 challenge. These findings indicate that the immune response to HSV2 in mice can be modulated through idiotype- antiidiotype networks, thereby increasing the pathogenicity of HSV2 infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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