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. 1984 Jun;50(3):960–963. doi: 10.1128/jvi.50.3.960-963.1984

Influenza viruses are T cell-independent B cell mitogens.

E M Anders, A A Scalzo, D O White
PMCID: PMC255767  PMID: 6610059

Abstract

UV-inactivated influenza virus A strains of subtypes H1, H2, H3, and H6 were shown to be mitogenic for unprimed splenic lymphocytes from BALB/c mice. Representative viruses of these four subtypes all behaved as T cell-independent B cell mitogens. The magnitude of the proliferative response was determined by the subtype of the hemagglutinin molecule: H2 and H6 viruses were the most potent mitogens, and H3 viruses were moderately mitogenic, whereas H1 viruses induced only low, but significant, levels of proliferation. Mitogenesis was inhibited by antiviral sera and by monoclonal antibodies directed against hemagglutinin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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