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. 1987 Oct;61(10):3222–3226. doi: 10.1128/jvi.61.10.3222-3226.1987

Transport of infectious reovirus into bile: class II major histocompatibility antigen-bearing cells determine reovirus transport.

D H Rubin, T Costello, C L Witzleben, M I Greene
PMCID: PMC255901  PMID: 3476756

Abstract

We have previously demonstrated that mammalian reovirus type 1 enters the bile and gut lumen after systemic administration. In the present study, we showed that Kupffer cell uptake is essential for the transport of reovirus into the bile. Furthermore, class II major histocompatibility antigen (I-A)-bearing cells are a major determinant for the transit of reovirus from the hepatic environment, as well as from the intestine, during the course of systemic infection. These findings may provide an approach to the control of viral pathogens that cause systemic disease by selective utilization or modification of I-A-bearing cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benacerraf B. Role of MHC gene products in immune regulation. Science. 1981 Jun 12;212(4500):1229–1238. doi: 10.1126/science.6165083. [DOI] [PubMed] [Google Scholar]
  2. Djeu J. Y., Heinbaugh J. A., Vieira W. D., Holden H. T., Herberman R. B. The effect of immunopharmacological agents on mouse natural cell-mediated cytotoxicity and on its augmentation by poly I:C. Immunopharmacology. 1979 Jun;1(3):231–244. doi: 10.1016/0162-3109(79)90040-7. [DOI] [PubMed] [Google Scholar]
  3. Gut J. P., Schmitt S., Bingen A., Anton M., Kirn A. Protective effect of colectomy in frog virus 3 hepatitis of rats: possible role of endotoxin. J Infect Dis. 1982 Nov;146(5):594–605. doi: 10.1093/infdis/146.5.594. [DOI] [PubMed] [Google Scholar]
  4. Ho D. D., Rota T. R., Schooley R. T., Kaplan J. C., Allan J. D., Groopman J. E., Resnick L., Felsenstein D., Andrews C. A., Hirsch M. S. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med. 1985 Dec 12;313(24):1493–1497. doi: 10.1056/NEJM198512123132401. [DOI] [PubMed] [Google Scholar]
  5. Joklik W. K. Studies on the effect of chymotrypsin on reovirions. Virology. 1972 Sep;49(3):700–715. doi: 10.1016/0042-6822(72)90527-2. [DOI] [PubMed] [Google Scholar]
  6. Klareskog L., Forsum U., Peterson P. A. Hormonal regulation of the expression of Ia antigens on mammary gland epithelium. Eur J Immunol. 1980 Dec;10(12):958–963. doi: 10.1002/eji.1830101212. [DOI] [PubMed] [Google Scholar]
  7. London S. D., Rubin D. H., Cebra J. J. Gut mucosal immunization with reovirus serotype 1/L stimulates virus-specific cytotoxic T cell precursors as well as IgA memory cells in Peyer's patches. J Exp Med. 1987 Mar 1;165(3):830–847. doi: 10.1084/jem.165.3.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Massa P. T., Dörries R., ter Meulen V. Viral particles induce Ia antigen expression on astrocytes. Nature. 1986 Apr 10;320(6062):543–546. doi: 10.1038/320543a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mayrhofer G., Pugh C. W., Barclay A. N. The distribution, ontogeny and origin in the rat of Ia-positive cells with dendritic morphology and of Ia antigen in epithelia, with special reference to the intestine. Eur J Immunol. 1983 Feb;13(2):112–122. doi: 10.1002/eji.1830130206. [DOI] [PubMed] [Google Scholar]
  10. Mayrhofer G., Schon-Hegrad M. A. Ia antigens in rat kidney, with special reference to their expression in tubular epithelium. J Exp Med. 1983 Jun 1;157(6):2097–2109. doi: 10.1084/jem.157.6.2097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mullock B. M., Hinton R. H., Dobrota M., Peppard J., Orlans E. Endocytic vesicles in liver carry polymeric IgA from serum to bile. Biochim Biophys Acta. 1979 Oct 18;587(3):381–391. doi: 10.1016/0304-4165(79)90442-2. [DOI] [PubMed] [Google Scholar]
  12. Owen R. L. Macrophage function in Peyer's patch epithelium. Adv Exp Med Biol. 1982;149:507–513. doi: 10.1007/978-1-4684-9066-4_71. [DOI] [PubMed] [Google Scholar]
  13. Papadimitriou J. M. Electron micrographic features of acute murine reovirus hepatitis. Am J Pathol. 1965 Oct;47(4):565–585. [PMC free article] [PubMed] [Google Scholar]
  14. Papadimitriou J. M. The biliary tract in acute murine reovirus 3 infection. Light and electron microscopic study. Am J Pathol. 1968 Mar;52(3):595–611. [PMC free article] [PubMed] [Google Scholar]
  15. Peterson T. C., Renton K. W. Kupffer cell factor mediated depression of hepatic parenchymal cell cytochrome P-450. Biochem Pharmacol. 1986 May 1;35(9):1491–1497. doi: 10.1016/0006-2952(86)90114-0. [DOI] [PubMed] [Google Scholar]
  16. Renston R. H., Jones A. L., Christiansen W. D., Hradek G. T., Underdown B. J. Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A. Science. 1980 Jun 13;208(4449):1276–1278. doi: 10.1126/science.7375938. [DOI] [PubMed] [Google Scholar]
  17. Richman L. K., Klingenstein R. J., Richman J. A., Strober W., Berzofsky J. A. The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen-specific T cell proliferation. J Immunol. 1979 Dec;123(6):2602–2609. [PubMed] [Google Scholar]
  18. Rubin D. H., Eaton M. A., Anderson A. O. Reovirus infection in adult mice: the virus hemagglutinin determines the site of intestinal disease. Microb Pathog. 1986 Feb;1(1):79–87. doi: 10.1016/0882-4010(86)90034-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rubin D. H., Eaton M. A., Costello T. Reovirus type 1 is secreted into the bile. J Virol. 1986 Nov;60(2):726–728. doi: 10.1128/jvi.60.2.726-728.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rubin D. H., Kornstein M. J., Anderson A. O. Reovirus serotype 1 intestinal infection: a novel replicative cycle with ileal disease. J Virol. 1985 Feb;53(2):391–398. doi: 10.1128/jvi.53.2.391-398.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sei Y., Petrella R. J., Tsang P., Bekesi J. G., Yokoyama M. M. Monocytes in AIDS. N Engl J Med. 1986 Dec 18;315(25):1611–1612. doi: 10.1056/NEJM198612183152512. [DOI] [PubMed] [Google Scholar]
  22. Smith R. E., Zweerink H. J., Joklik W. K. Polypeptide components of virions, top component and cores of reovirus type 3. Virology. 1969 Dec;39(4):791–810. doi: 10.1016/0042-6822(69)90017-8. [DOI] [PubMed] [Google Scholar]
  23. Steinman L., Rosenbaum J. T., Sriram S., McDevitt H. O. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7111–7114. doi: 10.1073/pnas.78.11.7111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wolf J. L., Rubin D. H., Finberg R., Kauffman R. S., Sharpe A. H., Trier J. S., Fields B. N. Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981 Apr 24;212(4493):471–472. doi: 10.1126/science.6259737. [DOI] [PubMed] [Google Scholar]

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