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. 1987 Oct;61(10):3284–3287. doi: 10.1128/jvi.61.10.3284-3287.1987

v-myb does not prevent the expression of c-myb in avian erythroblasts.

J S Lipsick
PMCID: PMC255909  PMID: 3041047

Abstract

The v-myb oncogene of avian myeloblastosis virus transforms myeloid cells exclusively, both in vivo and in vitro. The c-myb proto-oncogene from which v-myb arose is expressed at relatively high levels in immature hematopoietic cells of the lymphoid, erythroid, and myeloid lineages but not in myeloblasts transformed by v-myb. This finding suggested that the nuclear v-myb gene product p48v-myb might act directly to inhibit the normal expression of the c-myb gene. I have therefore used a selectable avian retroviral vector to express p48v-myb in avian erythroblasts which normally express high levels of the c-myb gene product p75c-myb. The results demonstrate that p48v-myb and p75c-myb can be coexpressed in the nuclei of cloned cells. Therefore, p48v-myb does not invariably prevent the expression of p75c-myb.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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