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. 1987 Dec;61(12):4026–4029. doi: 10.1128/jvi.61.12.4026-4029.1987

Superinfection of a chimpanzee with a second strain of human immunodeficiency virus.

P N Fultz 1, A Srinivasan 1, C R Greene 1, D Butler 1, R B Swenson 1, H M McClure 1
PMCID: PMC256026  PMID: 2446009

Abstract

Two chimpanzees, one (C-499) infected with the acquired immunodeficiency syndrome-associated retrovirus type 2 (ARV-2) strain of human immunodeficiency virus (HIV) and one (C-560) infected with the lymphadenopathy-associated virus type 1 (LAV-1) strain of HIV, were inoculated with approximately 10(4) tissue culture infective doses of the reciprocal strain. At the time of the second inoculation, both chimpanzees had high titers of HIV-specific antibodies, including antibodies that neutralized both virus strains. After inoculation of the second strain of HIV, the antibody titers in both chimpanzees increased 4- to 10-fold, and in one chimpanzee (C-499), the numbers of infectious peripheral blood mononuclear cells (PBMC) increased 1,000-fold to levels that are comparable with those observed after primary HIV infections. By restriction enzyme analysis of virus recovered from PBMC, both ARV-2 and LAV-1 were identified in C-499, thus demonstrating that superinfection had occurred.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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