Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1987 Dec;61(12):4043–4045. doi: 10.1128/jvi.61.12.4043-4045.1987

Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias.

D Bordereaux 1, S Fichelson 1, B Sola 1, P E Tambourin 1, S Gisselbrecht 1
PMCID: PMC256030  PMID: 2824835

Abstract

fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far. Proviruses are integrated in a 16-kilobase region, always in the same orientation. No RNA expression of fim-3 was detected.

Full text

PDF
4043

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cuypers H. T., Selten G. C., Zijlstra M., de Goede R. E., Melief C. J., Berns A. J. Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes. J Virol. 1986 Oct;60(1):230–241. doi: 10.1128/jvi.60.1.230-241.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gisselbrecht S., Fichelson S., Sola B., Bordereaux D., Hampe A., André C., Galibert F., Tambourin P. Frequent c-fms activation by proviral insertion in mouse myeloblastic leukaemias. Nature. 1987 Sep 17;329(6136):259–261. doi: 10.1038/329259a0. [DOI] [PubMed] [Google Scholar]
  3. Graham M., Adams J. M., Cory S. Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations. 1985 Apr 25-May 1Nature. 314(6013):740–743. doi: 10.1038/314740a0. [DOI] [PubMed] [Google Scholar]
  4. Moreau-Gachelin F., Robert-Lezenes J., Mathieu-Mahul D., Gisselbrecht S., Larsen C. J. Isolation and characterization of a gp 70+ non producer Friend tumor cell clone. Biochimie. 1983 Apr-May;65(4-5):259–266. doi: 10.1016/s0300-9084(83)80277-6. [DOI] [PubMed] [Google Scholar]
  5. Selten G., Cuypers H. T., Berns A. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J. 1985 Jul;4(7):1793–1798. doi: 10.1002/j.1460-2075.1985.tb03852.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Selten G., Cuypers H. T., Zijlstra M., Melief C., Berns A. Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO J. 1984 Dec 20;3(13):3215–3222. doi: 10.1002/j.1460-2075.1984.tb02281.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Shibuya T., Mak T. W. Host control of susceptibility to erythroleukemia and to the types of leukemia induced by Friend murine leukemia virus: initial and late stages. Cell. 1982 Dec;31(2 Pt 1):483–493. doi: 10.1016/0092-8674(82)90141-6. [DOI] [PubMed] [Google Scholar]
  8. Silver J. E., Fredrickson T. N. A new gene that controls the type of leukemia induced by Friend murine leukemia virus. J Exp Med. 1983 Aug 1;158(2):493–505. doi: 10.1084/jem.158.2.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sola B., Fichelson S., Bordereaux D., Tambourin P. E., Gisselbrecht S. fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemias. J Virol. 1986 Nov;60(2):718–725. doi: 10.1128/jvi.60.2.718-725.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Tsichlis P. N., Strauss P. G., Lohse M. A. Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis. J Virol. 1985 Oct;56(1):258–267. doi: 10.1128/jvi.56.1.258-267.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES