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. 1983 Jan;75(1):69–74.

Comparative Study of the Lipid Composition of Particular Pathogenic and Nonpathogenic Species of Mycobacterium

Arvind KN Nandedkar
PMCID: PMC2561434  PMID: 6402600

Abstract

A comparative study was undertaken of lipid composition of Mycobacterium tuberculosis H37Rv and H37Ra, M avium, M phlei, and M 607. Neutral lipids and phosphatides constituted about 55 and 25 percent of the total lipids, respectively. Seven different phosphatides were isolated and identified in varying proportions in all of the above species of mycobacteria. These were polyglycerophosphatide, phosphatidic acid, phosphatidylethanolamine, lysophosphatidylethanolamine, phosphatidylinositol, phosphatidylinositol dimannoside, and phosphatidylinositol pentamannoside. Choline-containing phosphatides and cholesterol (steroids) were not detected in lipids of any of the five species under these defined experimental culture medium and growth conditions. Interestingly enough, neutral lipids of M tuberculosis (H37Rv and H37Ra) contained a higher percentage of diglycerides than monoglycerides, whereas in the other species (M avium, M phlei, and M 607) the monoglyceride content exceeded that of the diglycerides. It appears that the lipid composition of mycobacteria can be an additional useful parameter in distinguishing pathogenic from nonpathogenic species of mycobacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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