Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1982 Aug;43(2):737–740. doi: 10.1128/jvi.43.2.737-740.1982

Chromosomal clustering of five defined endogenous retrovirus loci in White Leghorn chickens.

A Tereba, S M Astrin
PMCID: PMC256177  PMID: 7109040

Abstract

By using in situ hybridization, we localized three endogenous chicken retrovirus loci associated with the gs- chf- phenotype to distinct regions on chromosome 1. These three loci, ev4, ev5, and ev8, along with the two other known gs- chf--associated loci in White Leghorn chickens, ev1 and ev13, appear to be evenly distributed along chromosome 1, occurring approximately every 1.8 X 10(7) base pairs. The presence of all five loci on chromosome 1 represents a highly nonrandom distribution and all but eliminates a mechanism of independent random integration events for the generation of these loci.

Full text

PDF
737

Images in this article

739Image
on p.739

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ada G. L., Humphrey J. H., Askonas B. A., McDevitt H. O., Nossal G. J. Correlation of grain counts with radioactivity (125I and tritium) in autoradiography. Exp Cell Res. 1966 Mar;41(3):557–572. doi: 10.1016/s0014-4827(66)80106-4. [DOI] [PubMed] [Google Scholar]
  2. Astrin S. M. Endogenous viral genes of the White Leghorn chicken: common site of residence and sites associated with specific phenotypes of viral gene expression. Proc Natl Acad Sci U S A. 1978 Dec;75(12):5941–5945. doi: 10.1073/pnas.75.12.5941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Astrin S. M., Robinson H. L., Crittenden L. B., Buss E. G., Wyban J., Hayward W. S. Ten genetic loci in the chicken that contain structural genes for endogenous avian leukosis viruses. Cold Spring Harb Symp Quant Biol. 1980;44(Pt 2):1105–1109. doi: 10.1101/sqb.1980.044.01.119. [DOI] [PubMed] [Google Scholar]
  4. Astrin S. M., Robinson H. L. Gs, an allele of chickens for endogenous avian leukosis viral antigens, segregates with ev 3, a genetic locus that contains structural genes for virus. J Virol. 1979 Aug;31(2):420–425. doi: 10.1128/jvi.31.2.420-425.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ertl H. H., Feinendegen L. E., Heiniger H. J. Iodine-125, a tracer in cell biology: physical properties and biological aspects. Phys Med Biol. 1970 Jul;15(3):447–456. doi: 10.1088/0031-9155/15/3/005. [DOI] [PubMed] [Google Scholar]
  6. Frisby D. P., Weiss R. A., Roussel M., Stehelin D. The distribution of endogenous chicken retrovirus sequences in the DNA of galliform birds does not coincide with avian phylogenetic relationships. Cell. 1979 Jul;17(3):623–634. doi: 10.1016/0092-8674(79)90270-8. [DOI] [PubMed] [Google Scholar]
  7. Hayward W. S., Braverman S. B., Astrin S. M. Transcriptional products and DNA structure of endogenous avian proviruses. Cold Spring Harb Symp Quant Biol. 1980;44(Pt 2):1111–1121. doi: 10.1101/sqb.1980.044.01.120. [DOI] [PubMed] [Google Scholar]
  8. Hughes S. H., Shank P. R., Spector D. H., Kung H. J., Bishop J. M., Varmus H. E., Vogt P. K., Breitman M. L. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Dec;15(4):1397–1410. doi: 10.1016/0092-8674(78)90064-8. [DOI] [PubMed] [Google Scholar]
  9. Hughes S. H., Vogt P. K., Stubblefield E., Bishop J. M., Varmus H. E. Integration of avian sarcoma virus DNA in chicken cells. Virology. 1981 Jan 15;108(1):208–221. doi: 10.1016/0042-6822(81)90539-0. [DOI] [PubMed] [Google Scholar]
  10. Mason W. S., Linial M., Hsu T. W., Eisenman R. N., Townsend J., Mark G. E., Seal G., Aldrich C., Taylor J. M. Alterations in the genomes of avian sarcoma viruses. Virology. 1982 Mar;117(2):456–474. doi: 10.1016/0042-6822(82)90484-6. [DOI] [PubMed] [Google Scholar]
  11. Payne L. N., Chubb R. C. Studies on the nature and genetic control of an antigen in normal chick embryos which reacts in the COFAL test. J Gen Virol. 1968 Dec;3(3):379–391. doi: 10.1099/0022-1317-3-3-379. [DOI] [PubMed] [Google Scholar]
  12. Sabran J. L., Hsu T. W., Yeater C., Kaji A., Mason W. S., Taylor J. M. Analysis of integrated avian RNA tumor virus DNA in transformed chicken, duck and quail fibroblasts. J Virol. 1979 Jan;29(1):170–178. doi: 10.1128/jvi.29.1.170-178.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stehelin D., Varmus H. E., Bishop J. M., Vogt P. K. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976 Mar 11;260(5547):170–173. doi: 10.1038/260170a0. [DOI] [PubMed] [Google Scholar]
  14. Tereba A. 5'-terminal deletions are a common feature of endogenous retrovirus loci located on chromosome 1 of White Leghorn chickens. J Virol. 1981 Dec;40(3):920–926. doi: 10.1128/jvi.40.3.920-926.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tereba A., Astrin S. M. Chromosomal localization of ev-1, a frequently occurring endogenous retrovirus locus in white Leghorn chickens, by in situ hybridization. J Virol. 1980 Sep;35(3):888–894. doi: 10.1128/jvi.35.3.888-894.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tereba A., Crittenden L. B., Astrin S. M. Chromosomal localization of three endogenous retrovirus loci associated with virus production in White Leghorn chickens. J Virol. 1981 Jul;39(1):282–289. doi: 10.1128/jvi.39.1.282-289.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tereba A., Lai M. M. Cell oncogenes are located on the large microchromosomes in chicken cells. Virology. 1982 Jan 30;116(2):654–657. doi: 10.1016/0042-6822(82)90159-3. [DOI] [PubMed] [Google Scholar]
  18. Tereba A., Lai M. M., Murti K. G. Chromosome 1 contains the endogenous RAV-0 retrovirus sequences in chicken cells. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6486–6490. doi: 10.1073/pnas.76.12.6486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Weiss R. A., Mason W. S., Vogt P. K. Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses. Virology. 1973 Apr;52(2):535–552. doi: 10.1016/0042-6822(73)90349-8. [DOI] [PubMed] [Google Scholar]
  20. Wong T. C., Tereba A., Vogt P. K., Lai M. M. Characterization of the transformation-specific sequences of avian erythroblastosis virus in normal vertebrate cells. Virology. 1981 Jun;111(2):418–426. doi: 10.1016/0042-6822(81)90345-7. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES