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. Author manuscript; available in PMC: 2009 Mar 18.
Published in final edited form as: Nature. 2008 Sep 18;455(7211):323–332. doi: 10.1038/nature07370

Figure 7. Asymmetric phase-transfer alkylation toward indacrinone (40).

Figure 7

Merck scientists developed an enantioselective alkaloid salt-catalyzed phase-transfer enolate alkylation to gain access to indanone 39 with excellent stereoselectivity en route to the diuretic drug candidate indacrinone.84 (Reduced to 45%)