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. 1983 Jan;45(1):482–483. doi: 10.1128/jvi.45.1.482-483.1983

Epstein-Barr HR-1 Virion DNA Is Very Highly Methylated

Edward S Diala 1, Robert M Hoffman 1
PMCID: PMC256435  PMID: 6296457

Abstract

The virion DNA of Epstein-Barr virus strain HR-1 was found to be methylated to a very large extent, approaching 15%. This extent of methylation is in great contrast to other classes of tumor viruses, and it is the highest that we know of in any mammalian system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Diala E. S., Hoffman R. M. Hypomethylation of HeLa cell DNA and the absence of 5-methylcytosine in SV40 and adenovirus (type 2) DNA: analysis by HPLC. Biochem Biophys Res Commun. 1982 Jul 16;107(1):19–26. doi: 10.1016/0006-291x(82)91663-1. [DOI] [PubMed] [Google Scholar]
  2. Diala E. S., Plent M. M., Coalson D. W., Hoffman R. M. DNA methylation in normal and SV40-transformed human fibroblasts. Biochem Biophys Res Commun. 1981 Oct 30;102(4):1379–1384. doi: 10.1016/s0006-291x(81)80164-7. [DOI] [PubMed] [Google Scholar]
  3. Ford J. P., Coca-Prados M., Hsu M. T. Enzymatic analysis of 5-methylcytosine content in eukaryotic DNA. Study of intracellular Simian Virus 40 DNA. J Biol Chem. 1980 Aug 25;255(16):7544–7547. [PubMed] [Google Scholar]
  4. Gunthert U., Schweiger M., Stupp M., Doerfler W. DNA methylation in adenovirus, adenovirus-transformed cells, and host cells. Proc Natl Acad Sci U S A. 1976 Nov;73(11):3923–3927. doi: 10.1073/pnas.73.11.3923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kintner C., Sugden B. Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells. J Virol. 1981 Apr;38(1):305–316. doi: 10.1128/jvi.38.1.305-316.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Raab-Traub N., Pritchett R., Kieff E. DNA of Epstein-Barr virus. III. Identification of restriction enzyme fragments that contain DNA sequences which differ among strains of Epstein-Barr virus. J Virol. 1978 Aug;27(2):388–398. doi: 10.1128/jvi.27.2.388-398.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sharma S., Biswal N. Studies on the in vivo methylation of replicating herpes simplex virus type 1 DNA. Virology. 1977 Oct 15;82(2):265–274. doi: 10.1016/0042-6822(77)90002-2. [DOI] [PubMed] [Google Scholar]
  8. Vardimon L., Neumann R., Kuhlmann I., Sutter D., Doerfler W. DNA methylation and viral gene expression in adenovirus-transformed and -infected cells. Nucleic Acids Res. 1980 Jun 11;8(11):2461–2473. doi: 10.1093/nar/8.11.2461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Youssoufian H., Hammer S. M., Hirsch M. S., Mulder C. Methylation of the viral genome in an in vitro model of herpes simplex virus latency. Proc Natl Acad Sci U S A. 1982 Apr;79(7):2207–2210. doi: 10.1073/pnas.79.7.2207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. von Acken U., Simon D., Grunert F., Döring H. P., Kröger H. Methylation of viral DNA in vivo and in vitro. Virology. 1979 Nov;99(1):152–157. doi: 10.1016/0042-6822(79)90046-1. [DOI] [PubMed] [Google Scholar]

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