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. 1982 Feb;41(2):615–625. doi: 10.1128/jvi.41.2.615-625.1982

Guanidine-resistant defective interfering particles of poliovirus.

D R Tershak
PMCID: PMC256790  PMID: 6281472

Abstract

A mixture containing standard poliovirus and D3 particles (mutants with deletions in the capsid locus) was serially passaged in the presence of guanidine. Within five growth cycles, the standard virus was guanidine resistant, but the D3 particles were guanidine sensitive, even after 21 passages with the inhibitor. By passage 40 with guanidine, D3 particles were eliminated, and a new deletion mutant (DX) appeared in the virus population. D3 particles contained a 15% deletion, and DX particles contained a 6% deletion in the capsid locus. Although neither mutant induced the synthesis of NCVP1a or a complete complement of capsid proteins after infection, cells infected with DX particles produced two novel proteins, which had molecular weights of approximately 68,000 and 25,000.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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