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. 1982 Feb;41(2):721–725. doi: 10.1128/jvi.41.2.721-725.1982

Primate origin of the cell-derived sequences of simian sarcoma virus.

K C Robbins, R L Hill, S A Aaronson
PMCID: PMC256803  PMID: 6281482

Abstract

We sought to identify the species of origin of the cell-derived (sis) sequences of simian sarcoma virus. A molecular clone comprised of sis DNA detected related nucleotide sequences at low copy numbers in normal cellular DNAs of species as diverse as humans and quail. The extent of hybridization and degree of base-pair matching with sis DNA were greatest with New World primate DNAs. The thermal denaturation curve midpoints of hybrids formed between sis and woolly monkey DNAs were indistinguishable from homologous sis DNA hybrids, establishing the woolly monkey (Lagothrix spp.) as the source of sis sequences. In comparative studies, sis was shown to be more conserved among mammalian species than unique-sequence woolly monkey cellular DNA. There was no detectable homology between sis and the cell-derived sequences of other fibroblast-transforming retroviruses. These findings indicate that sis is likely to be a unique onc gene among transforming retroviruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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