Skip to main content
PMC home page
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 2004 Dec;96(12):1661–1667.

Correlation between Karnofsky Performance Status Scale and Short-Form Health Survey in patients on maintenance hemodialysis.

Fatiu A Arogundade 1, Bahaa Zayed 1, Maryam Daba 1, Rashad S Barsoum 1
PMCID: PMC2568667  PMID: 15622699

Abstract

BACKGROUND: Assessment of quality of life is vital inmonitoring response to various treatment measures. Various instruments, which include both generic and disease-specific instruments, are used in the assessment of health-related quality of life (HRQOL). In this study, we compare two commonly used generic instruments. OBJECTIVES: The objective of this study was to compare two generic instruments, the Karnofsky Performance Status Scale and the SF-36 Health Survey in hemodialysis (HD) patients. The study also aims to find out the association (if any) between HRQOL scores using these two scales and various clinical and biochemical parameters. MATERIALS AND METHODS: Sixty-two maintenance HD patients were recruited after informed consents were obtained. Detailed sociodemographic data was obtained. They were assessed during their regular HD sessions. Serum chemistry (which included serum urea, creatinine, Na+, K+, HCO3-, Ca2+, Po4(2-)), albumin, globulin, total protein and hemoglobin (g/dl) were assessed in all the patients. Adequacy of HD was assessed using second-generation Daugirdais formula. HRQOL was assessed using the Karnofsky and SSF-36 instruments and the scores collated and compared. Data was analyzed using SPSS version 10. RESULTS: Fifty-five patients completed the study (27 males and 28 females, mean age 40.76 +/- 11.05 years and age range of 20-65 years). There was a significant positive correlation between Karnofsky scores and all eight SF-36 domains, but only physical functioning, social functioning and role limitation due to emotional problems maintained the significance on multiple regression analysis. The serum creatinine and hemoglobin postively correlated with physical function, bodily pain, social functioning and Karnofsky scores. Age of the patients correlated negatively with two SF-36 dimensions (physical functioning and role limitation due to physical fitness) and Karnofsky scores. CONCLUSION: This study revealed a good correlation between Karnofsky performance status scale and the short-form (SF36) health survey in this Egyptian population. Age, serum creatinine and hemoglobin significantly influence quality of life in this HD patient population.

Full text

PDF
1661

Images in this article

1663Figure 1
on p.1663
1666Figure 2
on p.1666
1666Figure 3
on p.1666

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brazier J. E., Harper R., Jones N. M., O'Cathain A., Thomas K. J., Usherwood T., Westlake L. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992 Jul 18;305(6846):160–164. doi: 10.1136/bmj.305.6846.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Daugirdas J. T. Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol. 1993 Nov;4(5):1205–1213. doi: 10.1681/ASN.V451205. [DOI] [PubMed] [Google Scholar]
  3. Evans R. W., Manninen D. L., Garrison L. P., Jr, Hart L. G., Blagg C. R., Gutman R. A., Hull A. R., Lowrie E. G. The quality of life of patients with end-stage renal disease. N Engl J Med. 1985 Feb 28;312(9):553–559. doi: 10.1056/NEJM198502283120905. [DOI] [PubMed] [Google Scholar]
  4. Fujisawa M., Ichikawa Y., Yoshiya K., Isotani S., Higuchi A., Nagano S., Arakawa S., Hamami G., Matsumoto O., Kamidono S. Assessment of health-related quality of life in renal transplant and hemodialysis patients using the SF-36 health survey. Urology. 2000 Aug 1;56(2):201–206. doi: 10.1016/s0090-4295(00)00623-3. [DOI] [PubMed] [Google Scholar]
  5. Gill T. M., Feinstein A. R. A critical appraisal of the quality of quality-of-life measurements. JAMA. 1994 Aug 24;272(8):619–626. [PubMed] [Google Scholar]
  6. Gokal R., Figueras M., Ollé A., Rovira J., Badia X. Outcomes in peritoneal dialysis and haemodialysis--a comparative assessment of survival and quality of life. Nephrol Dial Transplant. 1999;14 (Suppl 6):24–30. doi: 10.1093/ndt/14.suppl_6.24. [DOI] [PubMed] [Google Scholar]
  7. Hutchinson T. A., Boyd N. F., Feinstein A. R., Gonda A., Hollomby D., Rowat B. Scientific problems in clinical scales, as demonstrated in the Karnofsky index of performance status. J Chronic Dis. 1979;32(9-10):661–666. doi: 10.1016/0021-9681(79)90096-1. [DOI] [PubMed] [Google Scholar]
  8. Iliescu Eduard A., Coo Helen, McMurray Margo H., Meers Carol L., Quinn Margo M., Singer Michael A., Hopman Wilma M. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant. 2003 Jan;18(1):126–132. doi: 10.1093/ndt/18.1.126. [DOI] [PubMed] [Google Scholar]
  9. Iseki K., Miyasato F., Tokuyama K., Nishime K., Uehara H., Shiohira Y., Sunagawa H., Yoshihara K., Yoshi S., Toma S. Low diastolic blood pressure, hypoalbuminemia, and risk of death in a cohort of chronic hemodialysis patients. Kidney Int. 1997 Apr;51(4):1212–1217. doi: 10.1038/ki.1997.165. [DOI] [PubMed] [Google Scholar]
  10. Knight Eric L., Ofsthun Norma, Teng Ming, Lazarus J. Michael, Curhan Gary C. The association between mental health, physical function, and hemodialysis mortality. Kidney Int. 2003 May;63(5):1843–1851. doi: 10.1046/j.1523-1755.2003.00931.x. [DOI] [PubMed] [Google Scholar]
  11. Kurtin P. S., Davies A. R., Meyer K. B., DeGiacomo J. M., Kantz M. E. Patient-based health status measures in outpatient dialysis. Early experiences in developing an outcomes assessment program. Med Care. 1992 May;30(5 Suppl):MS136–MS149. doi: 10.1097/00005650-199205001-00012. [DOI] [PubMed] [Google Scholar]
  12. Kutlay Sim, Nergizoglu Gokhan, Kutlay Sehim, Keven Kenan, Erturk Sehsuvar, Ates Kenan, Duman Neval, Karatan Oktay, Atli Teslime. General or disease specific questionnaire? A comparative study in hemodialysis patients. Ren Fail. 2003 Jan;25(1):95–103. doi: 10.1081/jdi-120017472. [DOI] [PubMed] [Google Scholar]
  13. Mapes Donna L., Lopes Antonio Alberto, Satayathum Sudtida, McCullough Keith P., Goodkin David A., Locatelli Francesco, Fukuhara Shunichi, Young Eric W., Kurokawa Kiyoshi, Saito Akira. Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Kidney Int. 2003 Jul;64(1):339–349. doi: 10.1046/j.1523-1755.2003.00072.x. [DOI] [PubMed] [Google Scholar]
  14. Mingardi G., Cornalba L., Cortinovis E., Ruggiata R., Mosconi P., Apolone G. Health-related quality of life in dialysis patients. A report from an Italian study using the SF-36 Health Survey. DIA-QOL Group. Nephrol Dial Transplant. 1999 Jun;14(6):1503–1510. doi: 10.1093/ndt/14.6.1503. [DOI] [PubMed] [Google Scholar]
  15. Moreno F., Sanz-Guajardo D., López-Gómez J. M., Jofre R., Valderrábano F. Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected hemodialysis patients. Spanish Cooperative Renal Patients Quality of Life Study Group of the Spanish Society of Nephrology. J Am Soc Nephrol. 2000 Feb;11(2):335–342. doi: 10.1681/ASN.V112335. [DOI] [PubMed] [Google Scholar]
  16. Rebollo P., Bobes J., González M. P., Saiz P., Ortega F. Factores asociados a la calidad de vida relacionada con la salud (CVRS) de los pacientes en terapia renal sustitutiva (TRS). Nefrologia. 2000 Mar-Apr;20(2):171–181. [PubMed] [Google Scholar]
  17. Rebollo P., Ortega F., Baltar J. M., Alvarez-Ude F., Alvarez Navascués R., Alvarez-Grande J. Is the loss of health-related quality of life during renal replacement therapy lower in elderly patients than in younger patients? Nephrol Dial Transplant. 2001 Aug;16(8):1675–1680. doi: 10.1093/ndt/16.8.1675. [DOI] [PubMed] [Google Scholar]
  18. Rosas Sylvia E., Joffe Marshall, Franklin Eunice, Strom Brian L., Kotzker Wayne, Brensinger Colleen, Grossman Eric, Glasser Dale B., Feldman Harold I. Association of decreased quality of life and erectile dysfunction in hemodialysis patients. Kidney Int. 2003 Jul;64(1):232–238. doi: 10.1046/j.1523-1755.2003.00042.x. [DOI] [PubMed] [Google Scholar]
  19. Vázquez Isabel, Valderrábano Fernando, Jofré Rosa, Fort Joan, López-Gómez Juan M., Moreno Fuensanta, Sanz-Guajardo Dámaso, Spanish Cooperative Renal Patients Quality of Life Study Group Psychosocial factors and quality of life in young hemodialysis patients with low comorbidity. J Nephrol. 2003 Nov-Dec;16(6):886–894. [PubMed] [Google Scholar]
  20. Welch J. L., Austin J. K. Quality of life in black hemodialysis patients. Adv Ren Replace Ther. 1999 Oct;6(4):351–357. doi: 10.1016/s1073-4449(99)70047-6. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES