Abstract
AIM: To determine the incidence, prevalence of type-1 diabetes mellitus (DM) and the presence of islet-cell antibodies (ICAs) in people of African ancestry in the Bahamas. METHOD: Hospital records of type-1 DM were reviewed. Seventeen consecutive patients had postmeal C-peptide and ICA determined. RESULTS: The incidence and prevalence of type-1 DM in the Bahamas were: incidence--10.1/100,000, age 0-14 years; and prevalence--31/100,000 age 0-24 years. Only two out of 17 (11.8%) patients had ICAs. CONCLUSION: Type-1 DM is common in children of African ancestry in the Bahamas. ICAs were absent in the majority of the patients.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Atkinson M. A., Eisenbarth G. S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001 Jul 21;358(9277):221–229. doi: 10.1016/S0140-6736(01)05415-0. [DOI] [PubMed] [Google Scholar]
- Buzzetti R., Quattrocchi C. C., Nisticò L. Dissecting the genetics of type 1 diabetes: relevance for familial clustering and differences in incidence. Diabetes Metab Rev. 1998 Jun;14(2):111–128. doi: 10.1002/(sici)1099-0895(199806)14:2<111::aid-dmr211>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Ellis T. M., Atkinson M. A. Early infant diets and insulin-dependent diabetes. Lancet. 1996 May 25;347(9013):1464–1465. doi: 10.1016/s0140-6736(96)91690-6. [DOI] [PubMed] [Google Scholar]
- Honeyman M. C., Coulson B. S., Stone N. L., Gellert S. A., Goldwater P. N., Steele C. E., Couper J. J., Tait B. D., Colman P. G., Harrison L. C. Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes. 2000 Aug;49(8):1319–1324. doi: 10.2337/diabetes.49.8.1319. [DOI] [PubMed] [Google Scholar]
- Jordan O. W., Lipton R. B., Stupnicka E., Cruickshank J. K., Fraser H. S. Incidence of type I diabetes in people under 30 years of age in Barbados, West Indies, 1982-1991. Diabetes Care. 1994 May;17(5):428–431. doi: 10.2337/diacare.17.5.428. [DOI] [PubMed] [Google Scholar]
- Kitabchi A. E., Umpierrez G. E., Murphy M. B., Barrett E. J., Kreisberg R. A., Malone J. I., Wall B. M. Management of hyperglycemic crises in patients with diabetes. Diabetes Care. 2001 Jan;24(1):131–153. doi: 10.2337/diacare.24.1.131. [DOI] [PubMed] [Google Scholar]
- Onkamo P., Vänänen S., Karvonen M., Tuomilehto J. Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends. Diabetologia. 1999 Dec;42(12):1395–1403. doi: 10.1007/s001250051309. [DOI] [PubMed] [Google Scholar]
- Strachan D. P. Hay fever, hygiene, and household size. BMJ. 1989 Nov 18;299(6710):1259–1260. doi: 10.1136/bmj.299.6710.1259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Todd J. A. From genome to aetiology in a multifactorial disease, type 1 diabetes. Bioessays. 1999 Feb;21(2):164–174. doi: 10.1002/(SICI)1521-1878(199902)21:2<164::AID-BIES10>3.0.CO;2-4. [DOI] [PubMed] [Google Scholar]
- Tull E. S., Roseman J. M., Christian C. L. Epidemiology of childhood IDDM in U.S. Virgin Islands from 1979 to 1988. Evidence of an epidemic in early 1980s and variation by degree of racial admixture. Diabetes Care. 1991 Jul;14(7):558–564. doi: 10.2337/diacare.14.7.558. [DOI] [PubMed] [Google Scholar]