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. 1982 Jun;42(3):865–872. doi: 10.1128/jvi.42.3.865-872.1982

Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls.

V S Hinshaw, G M Air, A J Gibbs, L Graves, B Prescott, D Karunakaran
PMCID: PMC256920  PMID: 7097861

Abstract

Influenza A virus isolates from ring-billed, Franklin, blackback, and herring gulls in the United States possess a hemagglutinin (HA) distinct from the 12 reference HA subtypes. Serological assays (hemagglutination inhibition and double-immunodiffusion) with specific antisera to reference strains and to a representative gull isolate showed that the HA of the gull virus was not antigenically related to that of any known subtype. The gull virus did not replicate in ducks or chickens but did replicate in ferrets. Comparison of the nucleotide sequences (and deduced amino acid sequences) of the 3' 20% of the HA genes of these viruses indicates that the gull viruses represent a genetically distinct group. We propose that this HA, which has been detected only in gull isolates thus far, be called the H13 subtype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Air G. M. Nucleotide sequence coding for the "signal peptide" and N terminus of the hemagglutinin from an asian (H2N2) strain of influenza virus. Virology. 1979 Sep;97(2):468–472. doi: 10.1016/0042-6822(79)90358-1. [DOI] [PubMed] [Google Scholar]
  2. Air G. M. Sequence relationships among the hemagglutinin genes of 12 subtypes of influenza A virus. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7639–7643. doi: 10.1073/pnas.78.12.7639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Becker W. B. The isolation and classification of Tern virus: influenza A-Tern South Africa--1961. J Hyg (Lond) 1966 Sep;64(3):309–320. doi: 10.1017/s0022172400040596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blok J., Air G. M. Comparative nucleotide sequences at the 3' end of the neuraminidase gene from eleven influenza type A viruses. Virology. 1980 Nov;107(1):50–60. doi: 10.1016/0042-6822(80)90271-8. [DOI] [PubMed] [Google Scholar]
  5. Gething M. J., Bye J., Skehel J., Waterfield M. Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus. Nature. 1980 Sep 25;287(5780):301–306. doi: 10.1038/287301a0. [DOI] [PubMed] [Google Scholar]
  6. Hall R. M., Air G. M. Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses. J Virol. 1981 Apr;38(1):1–7. doi: 10.1128/jvi.38.1.1-7.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hinshaw V. S., Bean W. J., Jr, Webster R. G., Easterday B. C. The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. Virology. 1978 Jan;84(1):51–62. doi: 10.1016/0042-6822(78)90217-9. [DOI] [PubMed] [Google Scholar]
  8. Hinshaw V. S., Webster R. G., Easterday B. C., Bean W. J., Jr Replication of avian influenza A viruses in mammals. Infect Immun. 1981 Nov;34(2):354–361. doi: 10.1128/iai.34.2.354-361.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hinshaw V. S., Webster R. G., Rodriguez R. J. Influenza A viruses: combinations of hemagglutinin and neuraminidase subtypes isolated from animals and other sources. Arch Virol. 1981;67(3):191–201. doi: 10.1007/BF01318130. [DOI] [PubMed] [Google Scholar]
  10. Hinshaw V. S., Webster R. G., Turner B. The perpetuation of orthomyxoviruses and paramyxoviruses in Canadian waterfowl. Can J Microbiol. 1980 May;26(5):622–629. doi: 10.1139/m80-108. [DOI] [PubMed] [Google Scholar]
  11. Hiti A. L., Davis A. R., Nayak D. P. Complete sequence analysis shows that the hemagglutinins of the H0 and H2 subtypes of human influenza virus are closely related. Virology. 1981 May;111(1):113–124. doi: 10.1016/0042-6822(81)90658-9. [DOI] [PubMed] [Google Scholar]
  12. Jou W. M., Verhoeyen M., Devos R., Saman E., Fang R., Huylebroeck D., Fiers W., Threlfall G., Barber C., Carey N. Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell. 1980 Mar;19(3):683–696. doi: 10.1016/s0092-8674(80)80045-6. [DOI] [PubMed] [Google Scholar]
  13. Lang G., Gagnon A., Geraci J. R. Isolation of an influenza A virus from seals. Arch Virol. 1981;68(3-4):189–195. doi: 10.1007/BF01314571. [DOI] [PubMed] [Google Scholar]
  14. Porter A. G., Barber C., Carey N. H., Hallewell R. A., Threlfall G., Emtage J. S. Complete nucleotide sequence of an influenza virus haemagglutinin gene from cloned DNA. Nature. 1979 Nov 29;282(5738):471–477. doi: 10.1038/282471a0. [DOI] [PubMed] [Google Scholar]
  15. Potter C. W., Oxford J. S., Shore S. L., McLaren C., Stuart-Harris C. Immunity to influenza in ferrets. I. Response to live and killed virus. Br J Exp Pathol. 1972 Apr;53(2):153–167. [PMC free article] [PubMed] [Google Scholar]
  16. Sanger F., Coulson A. R. The use of thin acrylamide gels for DNA sequencing. FEBS Lett. 1978 Mar 1;87(1):107–110. doi: 10.1016/0014-5793(78)80145-8. [DOI] [PubMed] [Google Scholar]
  17. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Skehel J. J., Hay A. J. Nucleotide sequences at the 5' termini of influenza virus RNAs and their transcripts. Nucleic Acids Res. 1978 Apr;5(4):1207–1219. doi: 10.1093/nar/5.4.1207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Slemons R. D., Easterday B. C. Virus replication in the digestive tract of ducks exposed by aerosol to type-A influenza. Avian Dis. 1978 Jul-Sep;22(3):367–377. [PubMed] [Google Scholar]
  20. Webster R. G. Antigenic hybrids of influenza A viruses with surface antigens to order. Virology. 1970 Nov;42(3):633–642. doi: 10.1016/0042-6822(70)90309-0. [DOI] [PubMed] [Google Scholar]
  21. Webster R. G., Hinshaw V. S., Bean W. J., Van Wyke K. L., Geraci J. R., St Aubin D. J., Petursson G. Characterization of an influenza A virus from seals. Virology. 1981 Sep;113(2):712–724. doi: 10.1016/0042-6822(81)90200-2. [DOI] [PubMed] [Google Scholar]
  22. Webster R. G., Isachenko V. A., Carter M. A new avian influenza virus from feral birds in the USSR: recombination in nature? Bull World Health Organ. 1974;51(4):325–332. [PMC free article] [PubMed] [Google Scholar]
  23. Webster R. G., Yakhno M., Hinshaw V. S., Bean W. J., Murti K. G. Intestinal influenza: replication and characterization of influenza viruses in ducks. Virology. 1978 Feb;84(2):268–278. doi: 10.1016/0042-6822(78)90247-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Winter G., Fields S., Brownlee G. G. Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype. Nature. 1981 Jul 2;292(5818):72–75. doi: 10.1038/292072a0. [DOI] [PubMed] [Google Scholar]

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