Abstract
Increased QT dispersion is associated with sudden cardiac death in congestive cardiac failure, hypertrophic cardiomyopathy and following myocardial infarction. Patients with hypertension--in particular, those with left ventricular hypertrophy (LVH)--are also at greater risk of sudden cardiac death. We examined whether QT dispersion, which is easily obtained from a routine ECG, correlates with LVH. One-hundred untreated patients with systemic hypertension and 78 normotensives had QT dispersion measured manually from a surface 12-lead electrocardiogram and two-dimensional echocardiography performed to measure interventricular septal thickness, posterior wall thickness and left ventricular internal diameter. Office blood pressure was also recorded. Multivariate analysis demonstrated significant relationships between QT dispersion and office systolic blood pressure, and left ventricular mass index. Manual measurement of QT dispersion might be a simple, noninvasive screening procedure to identify those hypertensives at greatest risk of sudden cardiac death in a third-world country.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alderman E. L. Results from late-breaking clinical trials sessions at ACC '98. American College of Cardiology. J Am Coll Cardiol. 1998 Jul;32(1):1–7. doi: 10.1016/s0735-1097(98)00204-6. [DOI] [PubMed] [Google Scholar]
- Barr C. S., Naas A., Freeman M., Lang C. C., Struthers A. D. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 1994 Feb 5;343(8893):327–329. doi: 10.1016/s0140-6736(94)91164-9. [DOI] [PubMed] [Google Scholar]
- Buja G., Miorelli M., Turrini P., Melacini P., Nava A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol. 1993 Oct 15;72(12):973–976. doi: 10.1016/0002-9149(93)91118-2. [DOI] [PubMed] [Google Scholar]
- Clarkson P. B., Naas A. A., McMahon A., MacLeod C., Struthers A. D., MacDonald T. M. QT dispersion in essential hypertension. QJM. 1995 May;88(5):327–332. [PubMed] [Google Scholar]
- Drayer J. I., Weber M. A., Gardin J. M., Lipson J. L. Effect of long-term antihypertensive therapy on cardiac anatomy in patients with essential hypertension. Am J Med. 1983 Sep 26;75(3A):116–120. doi: 10.1016/0002-9343(83)90128-6. [DOI] [PubMed] [Google Scholar]
- Frohlich E. D., Apstein C., Chobanian A. V., Devereux R. B., Dustan H. P., Dzau V., Fauad-Tarazi F., Horan M. J., Marcus M., Massie B. The heart in hypertension. N Engl J Med. 1992 Oct 1;327(14):998–1008. doi: 10.1056/NEJM199210013271406. [DOI] [PubMed] [Google Scholar]
- Hnatkova K., Malik M., Kautzner J., Gang Y., Camm A. J. Adjustment of QT dispersion assessed from 12 lead electrocardiograms for different numbers of analysed electrocardiographic leads: comparison of stability of different methods. Br Heart J. 1994 Oct;72(4):390–396. doi: 10.1136/hrt.72.4.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mayet J., Shahi M., McGrath K., Poulter N. R., Sever P. S., Foale R. A., Thom S. A. Left ventricular hypertrophy and QT dispersion in hypertension. Hypertension. 1996 Nov;28(5):791–796. doi: 10.1161/01.hyp.28.5.791. [DOI] [PubMed] [Google Scholar]
- McLenachan J. M., Henderson E., Morris K. I., Dargie H. J. Ventricular arrhythmias in patients with hypertensive left ventricular hypertrophy. N Engl J Med. 1987 Sep 24;317(13):787–792. doi: 10.1056/NEJM198709243171302. [DOI] [PubMed] [Google Scholar]
- Opadijo O. G., Omotoso A. B., Araoye M. A. Ventricular arrhythmias: Q-T prolongation and left ventricular hypertrophy in adult Nigerians with hypertensive heart disease. Niger Postgrad Med J. 2003 Jun;10(2):76–78. [PubMed] [Google Scholar]
- Prasquier R., Taradash M. R., Botvinick E. H., Shames D. M., Parmley W. W. The specificity of the diffuse pattern of cardiac uptake in myocardial infarction imaging with technetium-99m stannous pyrophosphate. Circulation. 1977 Jan;55(1):61–66. doi: 10.1161/01.cir.55.1.61. [DOI] [PubMed] [Google Scholar]
- Priori S. G., Aliot E., Blomstrom-Lundqvist C., Bossaert L., Breithardt G., Brugada P., Camm A. J., Cappato R., Cobbe S. M., Di Mario C. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J. 2001 Aug;22(16):1374–1450. doi: 10.1053/euhj.2001.2824. [DOI] [PubMed] [Google Scholar]
- Puddu P. E., Bourassa M. G. Prediction of sudden death from QTc interval prolongation in patients with chronic ischemic heart disease. J Electrocardiol. 1986 Jul;19(3):203–211. doi: 10.1016/s0022-0736(86)80030-9. [DOI] [PubMed] [Google Scholar]
- Pye M., Quinn A. C., Cobbe S. M. QT interval dispersion: a non-invasive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias? Br Heart J. 1994 Jun;71(6):511–514. doi: 10.1136/hrt.71.6.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sannerstedt R., Paulin S., Varnauskas E. Correlation between radiological chest findings and systemic haemodynamics in human arterial hypertension. Br Heart J. 1970 Jul;32(4):477–482. doi: 10.1136/hrt.32.4.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schouten E. G., Dekker J. M., Meppelink P., Kok F. J., Vandenbroucke J. P., Pool J. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation. 1991 Oct;84(4):1516–1523. doi: 10.1161/01.cir.84.4.1516. [DOI] [PubMed] [Google Scholar]
- Skudicky Daniel, Sareli Pinhas, Libhaber Elena, Candy Geoffrey, Radevski Ivo, Valtchanova Zdravska, Tshele Elizabeth, Thijs Lutgarde, Wang Ji-Guang, Staessen Jan A. Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial. Circulation. 2002 Feb 19;105(7):830–836. doi: 10.1161/hc0702.104162. [DOI] [PubMed] [Google Scholar]
