Abstract
Paradoxical deterioration during antituberculous therapy is defined as the clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in a patient who initially improves. Although it has frequently been reported for patients infected with human immunodeficiency virus (HIV), it can also be seen in HIV-negative patients. Here, we present a case of miliary tuberculosis in a patient who clinically deteriorates after antituberculous treatment, and discuss this confusing entity under the light of the pertinent literature.
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- Cheng V. C. C., Ho P. L., Lee R. A., Chan K. S., Chan K. K., Woo P. C. Y., Lau S. K. P., Yuen K. Y. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur J Clin Microbiol Infect Dis. 2002 Nov 7;21(11):803–809. doi: 10.1007/s10096-002-0821-2. [DOI] [PubMed] [Google Scholar]
- Fishman J. E., Saraf-Lavi E., Narita M., Hollender E. S., Ramsinghani R., Ashkin D. Pulmonary tuberculosis in AIDS patients: transient chest radiographic worsening after initiation of antiretroviral therapy. AJR Am J Roentgenol. 2000 Jan;174(1):43–49. doi: 10.2214/ajr.174.1.1740043. [DOI] [PubMed] [Google Scholar]
- Iijima N., Takada K., Ina Y., Itou S., Miyachi A., Kakihara H., Noda M., Hashiba H., Arakawa K., Sato T. [A case of miliary tuberculosis with prolonged high fever for more than 2 months under antituberculous therapy]. Kekkaku. 1990 Mar;65(3):231–235. [PubMed] [Google Scholar]
- Kiblawi S. S., Jay S. J., Stonehill R. B., Norton J. Fever response of patients on therapy for pulmonary tuberculosis. Am Rev Respir Dis. 1981 Jan;123(1):20–24. doi: 10.1164/arrd.1981.123.1.20. [DOI] [PubMed] [Google Scholar]
- Orlovic D., Smego R. A., Jr Paradoxical tuberculous reactions in HIV-infected patients. Int J Tuberc Lung Dis. 2001 Apr;5(4):370–375. [PubMed] [Google Scholar]