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. 2007 Feb;99(2):149–152.

A new perspective in diagnosing polycystic ovary syndrome.

Melek Eda Ertorer 1, Inan Anaforoglu 1, Emre Bozkirli 1, Okan Bakiner 1, Neslihan Bascil Tutuncu 1, Nilgun Guvener Demirag 1
PMCID: PMC2569430  PMID: 17366951

Abstract

Recently, the term of "possible" polycystic ovary syndrome (PCOS) has been used for defining cases in which biochemical evaluations are incomplete but clinical phenotypes are suggestive of PCOS. The aim of this study was, by using Rotterdam 2003 criteria, to detect possible PCOS cases and compare their characteristics and insulin sensitivity status with confirmed PCOS subjects. One-hundred-eighteen women who admitted with complaints and symptoms suggesting PCOS were included. Insulin sensitivity status of the cases was calculated with Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Cases fulfilling Rotterdam 2003 criteria were defined as confirmed PCOS, whereas indeterminate subjects as possible PCOS. Confirmed PCOS was detected in 70 (59.3%) and possible PCOS in 48 (40.7%) cases. Confirmed PCOS was most prevalent among subjects with hirsutism and menstrual dysfunction; 32 (80.0%) vs. 8 (20%), (p=0.000). Body mass index and HOMA-IR values did not differ between groups: confirmed PCOS versus possible PCOS; 25.46+/-5.55 kg/m(2) vs. 26.75+/-7.55 kg/m(2), 3.37+/-4.12 vs. 3.21+/-2.50, (p>0.05). Family history of type-2 diabetes mellifus was similar within both groups (p>0.05). Many PCOS patients seem to be undiagnosed due to inadherence to diagnostic work-up and/or to not fulfill Rotterdam 2003 criteria. These criteria may not be sufficient to cover the entire spectrum of PCOS.

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Selected References

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  1. Azziz R., Hincapie L. A., Knochenhauer E. S., Dewailly D., Fox L., Boots L. R. Screening for 21-hydroxylase-deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study. Fertil Steril. 1999 Nov;72(5):915–925. doi: 10.1016/s0015-0282(99)00383-0. [DOI] [PubMed] [Google Scholar]
  2. Azziz Ricardo. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature. J Clin Endocrinol Metab. 2006 Jan 17;91(3):781–785. doi: 10.1210/jc.2005-2153. [DOI] [PubMed] [Google Scholar]
  3. Azziz Ricardo, Marin Catherine, Hoq Lalima, Badamgarav Enkhe, Song Paul. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab. 2005 Jun 8;90(8):4650–4658. doi: 10.1210/jc.2005-0628. [DOI] [PubMed] [Google Scholar]
  4. Azziz Ricardo, Woods Keslie S., Reyna Rosario, Key Timothy J., Knochenhauer Eric S., Yildiz Bulent O. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004 Jun;89(6):2745–2749. doi: 10.1210/jc.2003-032046. [DOI] [PubMed] [Google Scholar]
  5. Ehrmann D. A., Rosenfield R. L. Clinical review 10: An endocrinologic approach to the patient with hirsutism. J Clin Endocrinol Metab. 1990 Jul;71(1):1–4. doi: 10.1210/jcem-71-1-1. [DOI] [PubMed] [Google Scholar]
  6. Ehrmann D. A., Sturis J., Byrne M. M., Karrison T., Rosenfield R. L., Polonsky K. S. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Jul;96(1):520–527. doi: 10.1172/JCI118064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hull M. G. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol. 1987 Sep;1(3):235–245. doi: 10.3109/09513598709023610. [DOI] [PubMed] [Google Scholar]
  8. Legro Richard S. Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev. 2003 Jun;24(3):302–312. doi: 10.1210/er.2003-0004. [DOI] [PubMed] [Google Scholar]
  9. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412–419. doi: 10.1007/BF00280883. [DOI] [PubMed] [Google Scholar]
  10. Ovalle Fernando, Azziz Ricardo. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril. 2002 Jun;77(6):1095–1105. doi: 10.1016/s0015-0282(02)03111-4. [DOI] [PubMed] [Google Scholar]
  11. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004 Jan;81(1):19–25. doi: 10.1016/j.fertnstert.2003.10.004. [DOI] [PubMed] [Google Scholar]
  12. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004 Jan;19(1):41–47. doi: 10.1093/humrep/deh098. [DOI] [PubMed] [Google Scholar]
  13. Venkatesan A. M., Dunaif A., Corbould A. Insulin resistance in polycystic ovary syndrome: progress and paradoxes. Recent Prog Horm Res. 2001;56:295–308. doi: 10.1210/rp.56.1.295. [DOI] [PubMed] [Google Scholar]

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