Skip to main content
NCBI home page
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 2006 Nov;98(11):1805–1808.

Low prevalence of hepatitis-C viral seropositivity among patients with type-2 diabetes mellitus in a tertiary hospital.

Williams Onabumeh Balogun 1, Jokotade Oluremilekun Adeleye 1, Kehinde Simeon Akinlade 1, Modupe Kuti 1, Jesse Abiodun Otegbayo 1
PMCID: PMC2569795  PMID: 17128691

Abstract

Recently, there have been increasing reports of high prevalence of hepatitis-C virus (HCV) in patients with type-2 diabetes, mostly in western nations. This suggests that type-2 diabetic patients could be considered to be at special risk of acquiring HCV and possibly that diabetes has an etiological relationship with HCV. Ninety patients with type-2 diabetes attending the medical outpatient clinic of the University College Hospital (UCH) and 90 nondiabetic controls with comparable age, sex and risk factors of exposure to HCV were recruited into the study. All subjects were screened for anti-HCV using a third-generation rapid enzyme immunoassay (Dialab anti-HCV cassette). Data were analyzed using Student's t test, Chi-squared test and Fisher's exact test. None of the diabetic patients tested positive for anti-HCV, while 1.1% of the control group tested positive for anti-HCV. There appears to be low prevalence of anti-HCV among type-2 diabetic patients in UCH Ibadan, and therefore no demonstrable risk of HCV in our patients.

Full text

PDF
1805

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Caronia S., Taylor K., Pagliaro L., Carr C., Palazzo U., Petrik J., O'Rahilly S., Shore S., Tom B. D., Alexander G. J. Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology. 1999 Oct;30(4):1059–1063. doi: 10.1002/hep.510300416. [DOI] [PubMed] [Google Scholar]
  2. Craighead J. E. Current views on the etiology of insulin-dependent diabetes mellitus. N Engl J Med. 1978 Dec 28;299(26):1439–1445. doi: 10.1056/NEJM197812282992605. [DOI] [PubMed] [Google Scholar]
  3. Madhava Valsa, Burgess Christine, Drucker Ernest. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis. 2002 May;2(5):293–302. doi: 10.1016/s1473-3099(02)00264-5. [DOI] [PubMed] [Google Scholar]
  4. Mangia A., Schiavone G., Lezzi G., Marmo R., Bruno F., Villani M. R., Cascavilla I., Fantasia L., Andriulli A. HCV and diabetes mellitus: evidence for a negative association. Am J Gastroenterol. 1998 Dec;93(12):2363–2367. doi: 10.1111/j.1572-0241.1998.00688.x. [DOI] [PubMed] [Google Scholar]
  5. Marcellin P., Martinot-Peignoux M., Elias A., Branger M., Courtois F., Level R., Erlinger S., Benhamou J. P. Hepatitis C virus (HCV) viremia in human immunodeficiency virus-seronegative and -seropositive patients with indeterminate HCV recombinant immunoblot assay. J Infect Dis. 1994 Aug;170(2):433–435. doi: 10.1093/infdis/170.2.433. [DOI] [PubMed] [Google Scholar]
  6. Mason A. L., Lau J. Y., Hoang N., Qian K., Alexander G. J., Xu L., Guo L., Jacob S., Regenstein F. G., Zimmerman R. Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology. 1999 Feb;29(2):328–333. doi: 10.1002/hep.510290235. [DOI] [PubMed] [Google Scholar]
  7. Okan V., Araz M., Aktaran S., Karsligil T., Meram I., Bayraktaroglu Z., Demirci F. Increased frequency of HCV but not HBV infection in type 2 diabetic patients in Turkey. Int J Clin Pract. 2002 Apr;56(3):175–177. [PubMed] [Google Scholar]
  8. Ola S. O., Otegbayo J. A., Odaibo G. N., Olaleye O. D., Olubuyide O. L. Serum hepatitis C virus and hepatitis B surface antigenaemia in Nigerian patients with acute icteric hepatitis. West Afr J Med. 2002 Jul-Sep;21(3):215–217. doi: 10.4314/wajm.v21i3.28033. [DOI] [PubMed] [Google Scholar]
  9. Olubuyide I. O., Ola S. O., Aliyu B., Dosumu O. O., Arotiba J. T., Olaleye O. A., Odaibo G. N., Odemuyiwa S. O., Olawuyi F. Hepatitis B and C in doctors and dentists in Nigeria. QJM. 1997 Jun;90(6):417–422. doi: 10.1093/qjmed/90.6.417. [DOI] [PubMed] [Google Scholar]
  10. Onyekwere C. A., Anomneze E. E., Wali S. S. Prevalence of serological markers of chronic hepatitis B virus infection in diabetics in the Lagos University Teaching Hospital, Lagos. Niger Postgrad Med J. 2002 Sep;9(3):129–133. [PubMed] [Google Scholar]
  11. Perret J. L., Moussavou-Kombila J. B., Delaporte E., Pemba L. F., Larouze B. Absence de lien entre infection par le virus de l'hépatite C et diabète au Gabon. Gastroenterol Clin Biol. 2000 Jan;24(1):135–136. [PubMed] [Google Scholar]
  12. Salako B. L., Ayodele O. E., Kadiri S., Arije A. Prevalence of hepatitis B and C viruses in pre-dialysis patients with chronic renal failure. Afr J Med Med Sci. 2002 Dec;31(4):311–314. [PubMed] [Google Scholar]
  13. Simó R., Hernández C., Genescà J., Jardí R., Mesa J. High prevalence of hepatitis C virus infection in diabetic patients. Diabetes Care. 1996 Sep;19(9):998–1000. doi: 10.2337/diacare.19.9.998. [DOI] [PubMed] [Google Scholar]
  14. Sotiropoulos A., Peppas T. A., Skliros E., Apostolou O., Kotsini V., Pappas S. I. Low prevalence of hepatitis C virus infection in Greek diabetic patients. Diabet Med. 1999 Mar;16(3):250–252. doi: 10.1046/j.1464-5491.1999.00009.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES