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Infection and Immunity logoLink to Infection and Immunity
. 1992 Apr;60(4):1714–1716. doi: 10.1128/iai.60.4.1714-1716.1992

Low biological activity of Helicobacter pylori lipopolysaccharide.

A Muotiala 1, I M Helander 1, L Pyhälä 1, T U Kosunen 1, A P Moran 1
PMCID: PMC257055  PMID: 1548097

Abstract

Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.

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Selected References

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