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. 1992 May;60(5):2110–2114. doi: 10.1128/iai.60.5.2110-2114.1992

Mapping of functional regions of Clostridium perfringens type A enterotoxin.

P C Hanna 1, E U Wieckowski 1, T A Mietzner 1, B A McClane 1
PMCID: PMC257123  PMID: 1373406

Abstract

Studies were conducted to allow construction of an initial map of the structure-versus-function relationship of the Clostridium perfringens type A enterotoxin (CPE). Removal of the N-terminal 25 amino acids of CPE increased the primary cytotoxic effect of CPE but did not affect binding. CPE sequences required for at least four epitopes were also identified.

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Selected References

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