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. 1992 May;60(5):2133–2135. doi: 10.1128/iai.60.5.2133-2135.1992

A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages.

R B Lorsbach 1, S W Russell 1
PMCID: PMC257128  PMID: 1563802

Abstract

Nitric oxide production by macrophages required either simultaneous or sequential exposure to gamma interferon and lipopolysaccharide; exposure to lipopolysaccharide followed by exposure to gamma interferon gave little response. The apparently evanescent nature of the lipopolysaccharide signal, necessitating persistent stimulation, could be essential to down-regulating nitric oxide production after bacteria are cleared in vivo.

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Selected References

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