Skip to main content
NCBI home page
Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 1986 Aug;78(8):782-784, 786.

Immunodiagnosis by Prostatic Acid Phosphatase to Differentiate Primary Male Breast Cancer From Metastatic Prostate Cancer

PP Kumar, Roger R Good, James R Newland
PMCID: PMC2571329  PMID: 3531533

Abstract

A patient who was treated with estrogens for carcinoma of the prostate was later diagnosed with apparent primary cancer of the male breast. He received chest-wall radiation therapy with curative intent. Later, immunodiagnosis by immunoperoxidase staining for human prostate-specific acid phosphatase of the breast tissue revealed that the patient actually had metastatic prostate cancer to the breast rather than primary breast cancer secondary to estrogen therapy. Use of highly specific peroxidase-antiperoxidase tissue staining for human prostate-specific acid phosphatase is recommended to differentiate primary male breast cancer from metastatic prostate cancer.

Full text

PDF
782

Images in this article

783Figure 1
on p.783
784Figure 2
on p.784

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRAMSON W., WARSHAWSKY H. Cancer of the breast in the male, secondary to estrogenic administration; report of a case. J Urol. 1948 Jan;59(1):76–82. doi: 10.1016/S0022-5347(17)69346-7. [DOI] [PubMed] [Google Scholar]
  2. BAUER D. D., ERICKSON R. L. Male breast cancer; Klinefelter syndrome with prostatic, adrenal and mammary tumors. Northwest Med. 1955 May;54(5):472–476. [PubMed] [Google Scholar]
  3. BENSON W. R. Carcinoma of the prostate with metastases to breasts and testis; critical review of the literature and report of a case. Cancer. 1957 Nov-Dec;10(6):1235–1245. doi: 10.1002/1097-0142(195711/12)10:6<1235::aid-cncr2820100622>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  4. BOUTOURAS G. D., WOODHAMS J. A., BROWN H. W. CARCINOMA OF THE MALE BREAST. J Int Coll Surg. 1965 Apr;43:390–396. [PubMed] [Google Scholar]
  5. CAMPBELI J. H., CUMMINS S. D. Metastases, simulating mammary cancer, in prostatic carcinoma under estrogenic therapy. Cancer. 1951 Mar;4(2):303–311. doi: 10.1002/1097-0142(195103)4:2<303::aid-cncr2820040215>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  6. CAMPBELL J. H., CUMMINS S. D., KIRK D. L., MATHEWS W. R. Secondary breast cancer of prostatic origin. JAMA. 1962 Feb 10;179:458–460. doi: 10.1001/jama.1962.03050060068016a. [DOI] [PubMed] [Google Scholar]
  7. CORBETT D. G., ABRAMS E. W. Bilateral carcinoma of the male breasts associated with prolonged stilbestrol therapy for carcinoma of the prostate. J Urol. 1950 Aug;64(2):377–381. doi: 10.1016/S0022-5347(17)68644-0. [DOI] [PubMed] [Google Scholar]
  8. Cortese A. F., Cornell G. N. Carcinoma of the male breast. Ann Surg. 1971 Feb;173(2):275–280. doi: 10.1097/00000658-197102000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. ENTZ F. H. Probable metastatic carcinoma of the male breast following stilbestrol therapy; case report. J Urol. 1948 Jun;59(6):1203–1207. doi: 10.1016/S0022-5347(17)69502-8. [DOI] [PubMed] [Google Scholar]
  10. FRANKS L. M. Estrogen-treated prostatic cancer: the variation in responsiveness of tumor ells. Cancer. 1960 May-Jun;13:490–501. doi: 10.1002/1097-0142(196005/06)13:3<490::aid-cncr2820130311>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  11. GRAVES G. Y., HARRIS H. S. Carcinoma of the male breast with axillary metastasis following stilbestrol therapy; report of a case treated by radical mastectomy. Ann Surg. 1952 Mar;135(3):411–414. doi: 10.1097/00000658-195203000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GUTHORN P. H. Carcinoma of the male breast: a report of fifteen cases. Mil Surg. 1951 Aug;109(2):110–114. [PubMed] [Google Scholar]
  13. GWYNNE J. F., DAWSON E. O. Carcinoma of the breast in a male with carcinoma of the prostate. Aust N Z J Surg. 1957 Feb;26(3):235–238. doi: 10.1111/j.1445-2197.1957.tb03787.x. [DOI] [PubMed] [Google Scholar]
  14. HERTZ R. The relationship between hormone-induced tissue growth and neoplasia: a review. Cancer Res. 1951 Jun;11(6):393–397. [PubMed] [Google Scholar]
  15. Holleb A. I., Freeman H. P., Farrow J. H. Cancer of male breast. II. N Y State J Med. 1968 Mar 1;68(5):656–663. [PubMed] [Google Scholar]
  16. JAKOBSEN A. H. I. Bilateral mammary carcinoma in the male following stilboestrol therapy. Acta Pathol Microbiol Scand. 1952;31(1):61–66. doi: 10.1111/j.1699-0463.1952.tb05055.x. [DOI] [PubMed] [Google Scholar]
  17. Jöbsis A. C., De Vries G. P., Anholt R. R., Sanders G. T. Demonstration of the prostatic origin of metastases: an immunohistochemical method for formalin-fixed embedded tissue. Cancer. 1978 May;41(5):1788–1793. doi: 10.1002/1097-0142(197805)41:5<1788::aid-cncr2820410521>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  18. LIEBEGOTT G. Follikelhormon und Mammakarzinom. Beitr Pathol Anat. 1952;112(2):235–242. [PubMed] [Google Scholar]
  19. LIEBEGOTT G. Mammacarcinom beim Mann nach Follikelhormonbehandlung. Klin Wochenschr. 1948 Oct 1;26(37-38):599–599. doi: 10.1007/BF01697552. [DOI] [PubMed] [Google Scholar]
  20. Li C. Y., Lam W. K., Yam L. T. Immunohistochemical diagnosis of prostatic cancer with metastasis. Cancer. 1980 Aug 15;46(4):706–712. doi: 10.1002/1097-0142(19800815)46:4<706::aid-cncr2820460412>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  21. Lome L. G., Austen G., Jr Metastatic breast carcinoma of prostatic origin. Am J Surg. 1970 Jul;120(1):113–115. doi: 10.1016/s0002-9610(70)80160-x. [DOI] [PubMed] [Google Scholar]
  22. Malek G. H., Madsen P. O. Carcinoma of the prostate with unusual metastases. Cancer. 1969 Jul;24(1):194–197. doi: 10.1002/1097-0142(196907)24:1<194::aid-cncr2820240124>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  23. McCLURE J. A., HIGGINS C. C. Bilateral carcinoma of male breast after estrogen therapy. J Am Med Assoc. 1951 May 5;146(1):7–9. doi: 10.1001/jama.1951.03670010011002. [DOI] [PubMed] [Google Scholar]
  24. Nadji M., Tabei S. Z., Castro A., Chu T. M., Morales A. R. Prostatic origin of tumors. An immunohistochemical study. Am J Clin Pathol. 1980 Jun;73(6):735–739. doi: 10.1093/ajcp/73.6.735. [DOI] [PubMed] [Google Scholar]
  25. O'Grady W. P., McDivitt R. W. Breast cancer in a man treated with diethylstilbestrol. Arch Pathol. 1969 Aug;88(2):162–165. [PubMed] [Google Scholar]
  26. REIMANN-HUNZIKER G. Brustdrüsenkarzinom nach Ovocyclinbehandlung eines Prostatakarzinoms. Helv Chir Acta. 1948 Jul;15(3):242–248. [PubMed] [Google Scholar]
  27. SCHWEINGRUBER B. Prostatakarzinom mit Metastasen in beiden Brustdrüsen nach Hormonbehandlung. Schweiz Med Wochenschr. 1956 Mar 24;86(12):314–315. [PubMed] [Google Scholar]
  28. Salyer W. R., Salyer D. C. Metastases of prostatic carcinoma to the breast. J Urol. 1973 Apr;109(4):671–675. doi: 10.1016/s0022-5347(17)60512-3. [DOI] [PubMed] [Google Scholar]
  29. Sternberger L. A., Hardy P. H., Jr, Cuculis J. J., Meyer H. G. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970 May;18(5):315–333. doi: 10.1177/18.5.315. [DOI] [PubMed] [Google Scholar]
  30. TREVES N., HOLLEB A. I. Cancer of the male breast; a report of 146 cases. Cancer. 1955 Nov-Dec;8(6):1239–1250. doi: 10.1002/1097-0142(1955)8:6<1239::aid-cncr2820080622>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the National Medical Association are provided here courtesy of National Medical Association

RESOURCES