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. 1992 Jun;60(6):2453–2458. doi: 10.1128/iai.60.6.2453-2458.1992

Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages.

G Källenius 1, T Koivula 1, K J Rydgård 1, S E Hoffner 1, A Valentin 1, B Asjö 1, C Ljungh 1, U Sharma 1, S B Svenson 1
PMCID: PMC257180  PMID: 1587613

Abstract

Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.

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Selected References

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