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. 1992 Jun;60(6):2470–2474. doi: 10.1128/iai.60.6.2470-2474.1992

The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine.

C A Lingwood 1, M Huesca 1, A Kuksis 1
PMCID: PMC257183  PMID: 1587616

Abstract

We have previously shown that Helicobacter pylori specifically binds to a glycerolipid species preferentially found in the antrum of the human stomach. We now show by high-pressure liquid chromatographic analysis that this species is a form of phosphatidylethanolamine and that H. pylori specifically binds to bona fide phosphatidylethanolamine as detected by a thin-layer chromatogram overlay procedure. Considerable variation in the binding of H. pylori to phosphatidylethanolamine from different sources was observed, however, suggesting the importance of the nature of the long-chain hydrophobic moiety. A similar binding specificity was shown by exoenzyme S from Pseudomonas aeruginosa, consistent with our hypothesis that that an exoenzyme S-like adhesin is responsible for the binding of H. pylori to its lipid receptors.

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Selected References

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