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. 1992 Jul;60(7):2777–2783. doi: 10.1128/iai.60.7.2777-2783.1992

Cross-reacting serum opsonins in patients with meningococcal disease.

H K Guttormsen 1, R Bjerknes 1, A Naess 1, V Lehmann 1, A Halstensen 1, S Sørnes 1, C O Solberg 1
PMCID: PMC257234  PMID: 1612745

Abstract

We have examined the opsonic activity of sera from patients with Neisseria meningitidis (B:15:P1.16) infections against different meningococcal strains, using flow cytometry and luminol-enhanced chemiluminescence. A marked increase in the phagocytosis of ethanol-fixed meningococcal strains of different serogroups, serotypes, and serosubtypes was demonstrated in the presence of convalescence sera compared with acute sera. Convalescence sera also caused a significant increase of leukocyte oxidative metabolism during phagocytosis, as measured by luminol-enhanced chemiluminescence. The sera contained a broad range of opsonins cross-reacting with serogroup A, B, C, W-135, and Y meningococci of different serotypes and serosubtypes, indicating that the cross-reacting opsonins recognized surface epitopes other than those determined by current serotyping schemes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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